COVID-19:n hoito ivermektiinillä (I-MASK+ -menetelmä)

Johdanto

Lyhyt katsaus

Aikajana

Muuta aineistoa

  • Muistiinpanoja kirjeenvaihdosta lääkäreiden, viranomaisten, tutkijoiden ja poliitikkojen kanssa (covidcare.fi).
  • Vastaus STM:n lausuntopyyntöön (VN/24131/2020). 12.11.2020 (covidcare.fi).
  • Ehdotus: FinCCHTA: I-MASK+ / ivermektiini. 16.11.2020 (covidcare.fi).
  • Ehdotus: FinCCHTA: MATH+. 16.11.2020 (covidcare.fi).

Meta-analyysi (@CovidAnalysis/ivmmeta.com -ryhmä)

  • Ivermektiini on vaikuttava COVID-19 -infektiossa: lähes reaaliaikaisesti päivitettävä meta-analyysi (ivmmeta.com).
  • Ajantasainen luettelo valmistuneista kliinisistä kokeista (c19ivermectin.com).
  • Ivermektiinin käyttöönoton tilanne kansainvälisesti (ivmstatus.com). Euroopassa ivermektiini on virallisesti otettu käyttöön COVID-19:n hoidossa Slovakiassa ja Tsekissä (tilanne 03/2021).
  • Ivermectin is effective for COVID-19: meta analysis of 52 studies. 30.4.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 46 studies. 17.3.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 43 studies. 4.3.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 41 studies. 18.2.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 35 studies. 20.1.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 32 studies. 13.1.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 28 studies. 2.1.2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 26 studies. 18.12.2020 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 21 studies. 26.11.2020 (covidcare.fi).
  • Arvio turhaan kuolleiden määrästä (c19legacy.com).

FLCCC-ryhmän hoitomenetelmät

I-MASK+ / ivermektiini

  • Yhden sivun yhteenveto ivermektiinitutkimuksesta (covid19criticalcare.com).
  • I-MASK+ -menetelmän perusteellinen kuvaus (covid19criticalcare.com). Laajempi tutkimuskatsaus.
  • Ivermectin — a potential global solution to the pandemic (covid19criticalcare.com). Suppeampi tutkimuskatsaus.
  • I-MASK+ -menetelmä (covid19criticalcare.com). Yleiskuvaus.
  • Paul E. Marik: COVID-19 Rx Meta-analysis, 25.11.2020 (covidcare.fi). Kliinisten kokeiden meta-analyysi.
  • FAQ on ivermectin (covid19criticalcare.com).
  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. American Journal of Therapeutics 2021. doi: 10.1097/MJT.0000000000001377 (journals.lww.com).

MATH+

  • Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org). MATH+ -menetelmän perusteet vertaisarvioituna artikkelijulkaisuna.
  • Scientific Review of COVID-19 and MATH+ (covid19criticalcare.com). Katsaus menetelmän perusteisiin.
  • MATH+ käännöksineen (covid19criticalcare.com). MATH+ -menetelmän yleiskuvaus.
  • Eastern Virginia Medical School: COVID Care Protocol for Clinicians (www.evms.edu). Yksityiskohtaisempi ja nopeammin päivittyvä "alkuperäinen" versio protokollasta. Ivermektiini on ollut vaihtoehtoinen komponentti 11.5.2020 alkaen mutta se on nostettu olennaiseksi komponentiksi 29.10.2020 alkaen.

Kehittäjätiimi

Professori Marik on julkaissut yli 400 vertaisarvioitua akateemista artikkelia ja huomattavan määrän muita julkaisuja (h-indeksi 93, 33700 viittausta). Professori Gianfranco Umberto Medurin h-indeksi on 66 ja hänellä on 19100 viittausta. Professori Joseph Varonin h-indeksi on 45 (9100 viittausta). Apulaisprofessori Pierre Koryn h-indeksi on 16 (lähes 1000 viittausta). Apulaisprofessori Jose Iglesiasin h-indeksi on 15 (yli 700 viittausta). Lisäksi tiimiin kuuluu muita asiantuntijoita.

Akateemisia julkaisuja and kliinisiä kokeita

Julkaisuluettelo on 1.12.2020 tasalla. Ks. myös ajantasainen ja kattava RCT-katsaus sivulla c19ivermectin.com ja meta-analyysi sivulla ivmmeta.com. Tässä osassa on kuitenkin katsaus- ja teorialähteitä ivermektiinistä sekä lähteitä MATH+ -metodista, joita ei mainita em. sivuilla.

Ivermektiini: ennaltaehkäisyä koskevia kliinisiä kokeita

  • Shouman W et.al: Prophylactic Ivermectin in COVID-19 Contacts. NCT04422561. 27.8.2020 (clinicaltrials.gov). 7 % sai tartunnan vs. 58 % vertailuryhmässä.
  • Carvallo HE et.al.: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR). NCT04425850. 19.11.2020 (clinicaltrials.gov). 0 % sai tartunnan vs. 11 % vertailuryhmässä.
  • Behera P, Patro BK, Singh AK, et al.: Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study. 3.11.2020 (doi.org). 73 % vähemmän infektioita.
  • Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. 16.11.2020 (doi.org). 2 % sai tartunnan vs. 10 % vertailuryhmässä.

Ivermektiini: sairaalahoitoa koskevia kliinisiä kokeita

  • Mahmud R. et.al.: Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection (NCT04523831) (clinicaltrials.gov). Results: early clinical improvement: 60% vs 44%; late clinical improvement: 23% vs 37%; clinical deterioration: 8% vs 18%; persistently RT-PCR positive: 8% vs 20%; adverse events: 2 vs 0; deaths: 0 vs 3
  • Hashim HA, Maulood MF, Rasheed AM, Fatak DF, Kabah KK, Abdulamir AS: Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq (NCT04591600). medRxiv 27.10.2020 (www.medrxiv.org). pienempi kuolleisuus ja lyhentyneet hoitoajat.
  • Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. 16.11.2020 (doi.org). 90 % pienempi kuolleisuus; lyhyempi sairaalassaoloaika.
  • Niaee MS, Gheibi N, Namdar P, Allami A, Zolghadr L, Javadi A, Karampour A, Varnaseri M, Bizhani B, Cheraghi F, Naderi Y, Amini F, Karamyan M, Yadyad MJ, Jamshidian R: Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial. Research Square 24.11.2020 (doi.org). 82 % alempi kuolleisuus.
  • Krolewiecki, Alejandro and Lifschitz, Adrián and Moragas, Matías and Travacio, Marina and Valentini, Ricardo and Alonso, Daniel F. and Solari, Rubén and Tinelli, Marcelo Adrián and Cimino, Ruben Oscar and Álvarez, Luis and Fleitas, Pedro Emanuel and Ceballos, Laura and Golemba, Marcelo Darío and Fernández, Florencia and Fernández de Oliveira, Diego and Astudillo, Germán and Baeck, Inés and Farina, Javier and Guthmann, Marcelo David and Cardama, Georgina A. and Mangano, Andrea and Spitzer, Eduardo and Gold, Silvia and Lanusse, Carlos, Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial. SSRN Electronic Journal 2020. (doi.org). merkittävästi pienempi viruskuorma potilailla, joilla ivermektiinin plasmapitoisuudet olivat korkeat.

Ivermektiini: vertailevia tutkimuksia

  • Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter J-J: Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019. Chest 2020 (doi.org). kuolleisuus 13 % vs. 25 %.
  • Hellwig MD, Maia A: A COVID-19 Prophylaxis? Lower incidence associated with prophylactic administration of Ivermectin. International Journal of Antimicrobial Agents 2020;106248 (doi.org). 80 % vähemmän tartuntoja.
  • Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O: Bénéfice de l’ivermectine : de la gale à la COVID-19, un exemple de sérendipité. Annales de Dermatologie et de Vénéréologie 2020;147(12):A194 (doi.org). 0 % vs. 5 % kuolleisuus, 0 % vs 22.6 % vakava sairausmuoto.
  • Guerrero R, Bravo L, Muñoz E, Grillo Ardila E, Guerrero E: COVID-19: The Ivermectin African Enigma. Colombia Médica 2020;51(4):e-2014613 (colombiamedica.univalle.edu.co).
  • Brian C. Procter, Casey Ross, Vanessa Pickard, Erica Smith, Cortney Hanson, Peter A. McCullough. Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection. Reviews in Cardiovascular Medicine 2020;21(4):611–4 (doi.org).

Ivermektiini: pitkittynyt / post-akuutti syndrooma

  • Aguirre Chang G, Saavedra E, Yui Cerna M, Trujillo Figueredo A, Córdova Masías JA: Post-acute or prolonged COVID-19: Treatment with ivermectin for patients with persistent or post-acute symptoms. ResearchGate 2020 (www.researchgate.net).

Ivermektiini: katsauksia ja teoriaa

  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. Front Pharmacol 2021. doi: 10.3389/fphar.2021.643369 (web.archive.org).
  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19. OSF Preprints 2020 (osf.io).
  • Andrew Hill, Ahmed Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn McCann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel: Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection. Research Square 19.1.2021 (doi.org). The "WHO meta-analysis".
  • Scheim D: Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion. SSRN Electronic Journal, 26.6.2020 (doi.org).
  • Chamie J: Real-World Evidence: The Case of Peru. Causality between Ivermectin and COVID-19 Infection Fatality Rate. 2020 (www.researchgate.net).
  • Pandey S, Pathak SK, Pandey A, Salunke AA, Chawla J, Sharma A, Sharma S, Thivari P, Ratha HVK: Ivermectin in COVID-19: What do we know? Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2020;14(6):1921-2. (doi.org).
  • Sparavigna AC: Ivermectin for Covid-19. Working paper. Zenodo 20.9.2020 (doi.org).
  • Elkholy KO, Hegazy O, Erdinc B, Abowali H: Ivermectin: A Closer Look at a Potential Remedy. Cureus 2020. (doi.org).
  • Scheim D: Antimalarials for COVID-19 Treatment: Rapid Reversal of Oxygen Status Decline with the Nobel Prize-Honored Macrocyclic Lactone Ivermectin. SSRN Electronic Journal 3.6.2020 (doi.org).
  • Rizzo E: Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. Naunyn Schmiedebergs Arch Pharmacol 2020 May 27: 1–4. PMC7251046 (doi.org).
  • Morgenstern J, Redondo JN, De León A, Canela JM, Torres N, Tavares J, Minaya M, López Ó, Plácido AM, Castillo A, Peña Cruz R, Merette Y, Toribio M, Francisco JA, Roca S: The use of compassionate Ivermectin in the management of symptomatic outpatients and hospitalized patients with clinical diagnosis of COVID-19 at the Medical Center Bournigal and the Medical Center Punta Cana, Rescue Group, Dominican Republic, from may 1 to august 10, 2020. medRxiv 2020.10.29.20222505. 3.11.2020 (doi.org).
  • Parth Sarthi Sen Gupta and Satyaranjan Biswal and Saroj Kumar Panda and Abhik Kumar Ray and Malay Kumar Rana: Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin. Journal of Biomolecular Structure and Dynamics 2020 (doi.org).
  • Lawrie T: Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance. E-BMC Ltd 3.1.2021 (bit.ly).
  • McCullough PA, Alexander PE, Armstrong R, Arvinte C, Bain AF, Bartlett RP, et al.: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine 2020;21(4):517-530 (doi.org).
  • Ramírez, Céleo et al.: Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis? Lancet EClinicalMedicine, 100744, Feb 4, 2021 (doi.org).

MATH+

  • Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org).
  • Marik PE, Kory P, Varon J, Iglesias J, Meduri GU. MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale. Expert Rev Anti Infect Ther 2020;18:1-7. doi: 10.1080/14787210.2020.1808462. PMID: 32809870 (covid19criticalcare.com).
  • Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H, Peng Z-Y: Pilot Trial of High-dose vitamin C in critically ill COVID-19 patients. Preprint. Research Square 23.9.2020 (doi.org).
  • Kory P, Kanne JP: SARS-CoV-2 organising pneumonia: Has there been a widespread failure to identify and treat this prevalent condition in COVID-19? BMJ Open Respiratory Research 2020;7:e000724 (doi.org). Explains the 'happy hypoxia'.
  • Arvinte C, Singh M, Marik PE: Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020. A pilot study. Medicine in drug discovery 2020 (doi.org). This pilot study found low serum levels of vitamin C and vitamin D in most of the critically ill COVID-19 ICU patients. Older age and low vitamin C level appeared co-dependent risk factors for mortality.
  • Chiscano-Camón L, Ruiz-Rodriguez J, Ruiz-Sanmartin A et al.: Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care 2020;24:522 (doi.org).
  • Honore PM, Spapen HD, Marik PE et. al.: Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care 2020;10:23 (doi.org).
  • Jovic TH, Ali SR, Ibrahim N, Jessop ZM, Tarassoli SP, Dobbs TD, Holford P, Thornton CA, Whitaker IS: Could Vitamins Help in the Fight Against COVID-19? Nutrients 2020;12:2550 (doi.org).
  • Marik PE, Payen D: CITRIS-ALI: How statistics were used to obfuscate the true findings. Anaesthesia Critical Care & Pain Medicine 2019;38(6):575–577. Doi: 10.1016/j.accpm.2019.10.004 (www.researchgate.net).
  • Fowler AA, Fisher BJ, Kashiouris MG: Vitamin C for Sepsis and Acute Respiratory Failure. JAMA 2020;323(8):792–3 (doi.org). CITRIS-ALI -raportin metodisten virheiden korjaus, jonka seurauksena mSOFA-mittari muuttuu tilastollisesti merkitseväksi 96 tunnin kohdalla.
  • Frommelt MA, Kory P, Long MT: Letter on Update to the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Protocol. Trials 2020;21:350 (doi.org).
  • Fowler AA, Syed AA, Knowlson S et. al.: Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014;12:32 (doi.org). Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
  • Mao E: Intensive management of severe acute pancreatitis. Annals of Translational Medicine 2019;7(22) (atm.amegroups.com). High-dose intravenous vitamin C has been routinely used for various conditions in some intensive care units in China for a decade.
  • Hemilä H, Chalker E: Vitamin C as a Possible Therapy for COVID-19. Infection & Chemotherapy 2020;52(2):222-223 (doi.org).

Uutisartikkeleita

I-MASK+ / ivermektiini

  • How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru. TrialSite News 12.6.2020 (www.trialsitenews.com).
  • Well-Respected Australian Researcher: Consider Triple Therapy (Ivermectin, Zinc, Doxycycline) for COVID-19. TrialSite News 4.8.2020 (www.trialsitenews.com).
  • Australian GPs Can Legally Prescribe Ivermectin Triple Therapy Protocol — Professor Thomas Borody. 19.8.2020 (covexit.com).
  • Argentina’s IVERCAR Ivermectin & Carrageenan Study Shows Positive Results Targeting COVID-19. TrialSite News 3.9.2020 (www.trialsitenews.com).
  • An Old Drug Tackles New Tricks: Ivermectin Treatment in Three Brazilian Towns. TrialSite News 16.9.2020 (www.trialsitenews.com).
  • Ivermectin Works and Should be Accepted for Large Observational Studies. Trialsite News 28.10.2020 (www.trialsitenews.com).
  • Real World Evidence? I-MASK+ Protocol: Ivermectin Key for Prophylaxis and Early Treatment of COVID-19. TrialSite News 3.11.2020 (www.trialsitenews.com).
  • Benha University Breakthrough: Randomized Controlled Trial Shows Ivermectin Effective for Treating COVID-19 & as Prophylaxis. TrialSite News, 14.11.2020 (www.trialsitenews.com).
  • Why Isn’t Ivermectin Being Widely Researched and Utilized? TrialSite News 15.11.2020 (www.trialsitenews.com).
  • Joseph A. Ladapo: Too Much Caution Is Killing Covid Patients. Doctors should follow the evidence for promising therapies. Instead they demand certainty. Wall Street Journal 24.11.2020 (www.wsj.com).
  • Carvallo H. et.al.: Resultados positivos del protocolo IVER.CAR en la profilaxis de los agentes de salud. 2020 (www.pharmabaires.com).
  • ICDDR Dhaka Bangladesh Completes Successful Ivermectin Clinical Trial. TrialSite News, 9.12.2020 (trialsitenews.com).
  • US Senate Hearing Explores Ivermectin as “Miracle Drug” for COVID-19 While Mainstream Media Outlets Ignore. TrialSite News, 11.12.2020 (trialsitenews.com).
  • Introducing the Physicians for Civil Defense: Prominent Doctors Know Ivermectin can Help Treat COVID-19: Will Anyone Listen? TrialSite News, 11.12.2020 (trialsitenews.com).
  • Beyond The Roundup | Senate Hearing On Ivermectin Brings Unexpected Drama. TrialSite News, 12.12.2020 (trialsitenews.com).
  • Fact Checking the Fact Checkers: The Case of Ivermectin for Publicly-Subsidized Research. TrialSite News, 13.12.2020 (trialsitenews.com).
  • Interview with Lawyer Jean-Charles Teissedre about Ivermectin. Covexit 13.12.2020 (covexit.com).
  • Clinical Trials and Research Roundup | Doctors: Ivermectin Can Help Treat COVID: Will Anyone Listen? TrialSite News, 14.12.2020 (trialsitenews.com).
  • Prasad, Amit Mohan: From control rooms to testing, several strategies helped UP contain pandemic. The Indian Express 17.12.2020 (indianexpress.com). Uttar Pradesh on käyttänyt ivermektiiniä ennaltaehkäisyyn ja avohoitoon heinäkuusta alkaen, ja ivermektiiniä ja doksisykliiniä sairaalahoidossa.
  • Bangladesh Medical College Observational Study: Ivermectin Works as PrEP for Health Care Workers Against COVID-19. TrialSite News, 17.12.2020 (trialsitenews.com).
  • Webinar with Professor Paul Marik: the Prevention & Outpatient Treatment of C19. Covexit 17.12.2020 (covexit.com).
  • MedinCell’s Mission for ‘Mass Roll-out’ of Ivermectin for COVID-19: Early Study Data Points Reveal Promise. TrialSite News, 18.12.2020 (trialsitenews.com).
  • Ivermectin Shows Potential as a Promising COVID-19 Prophylactic According to Study Published in Peer-Review Journal. TrialSite News, 19.12.2020 (trialsitenews.com).
  • Ivermectin to Save Belgium? Covexit 22.12.1010 (covexit.com).
  • MALMED will approve Ivermectin, but then will ask the pharmaceutical companies to bring it because "it is not a cure for business". 24.12.2020 (www.slobodenpecat.mk).
  • Bulgarian Prof. Ivo Petrov: Ivermectin Plays The Role of A Live Vaccine. 24.12.2020 (www.novinite.com).
  • Did you Hear about the ZIVERDO Therapy for COVID-19? Covexit 26.12.2020 (covexit.com).
  • Mary Beth Pfeiffer: In Far-Flung Places, COVID-19 Is Being Treated Early And Well. Here’s Why Americans Don’t Know This. TrialSite News 27.12.2020 (trialsitenews.com).
  • Macedonia Nears Approval of Ivermectin for COVID-19 as Word of the Drug Spreads in the Balkan Peninsula. TrialSite News 28.12.2020 (trialsitenews.com).
  • Unitaid, Part of the World Health Organization Funding Ivermectin Research Targeting COVID-19 led by British Expert. TrialSite News 29.12.2020 (trialsitenews.com).
  • Can Ivermectin be used to treat COVID-19 (coronavirus)? Drugs.com 29.12.2020 (www.drugs.com).
  • Beyond The Roundup | Central American Nation of Belize Authorizes Use of Ivermectin for COVID-19. TrialSite News 30.12.2020 (trialsitenews.com).
  • Prof. Ivo Petrov for Ivermectin: The Study Is Over, The Results Are Encouraging. 31.12.2020 (www.novinite.com).
  • WHO-sponsored preliminary review indicates Ivermectin effectiveness. 31.12.2020 (swprs.org).
  • Paul E. Sax: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? NEJM Journal Watch 4.1.2021 (blogs.jwatch.org).
  • NIH COVID-19 Treatment Guidelines Panel Invites Top Ivermectin Researchers to Discuss the Evidence of Efficacy to Date. 8.1.2020 (trialsitenews.com).
  • Growing Momentum for Ivermectin in German Press as Pharmacy Journal Introduces Ivermectin as Possible Treatment for COVID-19. TrialSite News 17.1.2021 (trialsitenews.com).
  • Barcelona Institute for Global Health (ISGlobal): A clinical trial provides encouraging results on ivermectin for reducing mild COVID-19. 19.1.2021 (www.eurekalert.org).
  • Donato Paolo Mancini: Cheap antiparasitic could cut chance of Covid-19 deaths by up to 75%. Financial Times 20.1.2021 (www.ft.com).
  • Spanish Pilot Study Reveals Ivermectin Can Possibly Reduce Viral Transmission. TrialSite News 21.1.2021 (trialsitenews.com).
  • Rhys Blakely: Trial for Covid ‘wonder drug’ that could save thousands of lives. The Times (UK), 23.1.2021 (www.thetimes.co.uk).
  • Ministério Público Federal (Brazil): Covid-19: Conselho Federal de Medicina ressalta autonomia do médico e do paciente na utilização de medicamentos e procedimentos. 23.1.2021 (www.mpf.mp.br). physicians are officially allowed autonomous decisions regarding treatment of COVID-19 patients.
  • Financial Times Adds to Argument for Ivermectin. TrialSite News 23.1.2021 (trialsitenews.com).
  • Oxford’s PRINCIPLE Trial: Bringing Ivermectin Directly into the Developed World in the Battle Against COVID-19. TrialSite News 23.1.2021 (trialsitenews.com).
  • Jackie Cameron: Ivermectin: Major tech breakthrough in human application, as scientists aim to save world from Covid-19 and malaria. 11.2.2021 (www.biznews.com).
  • Belgian Virologist Proposes a Plan to Eradicate COVID-19 in 6 Weeks Using Ivermectin. TrialSite News 13.2.2021 (trialsitenews.com).
  • Beyond The Roundup | Bill and Melinda Gates Fund Global Ivermectin Clinical Trial. TrialSite News 13.2.2021 (trialsitenews.com).
  • Merck Spends Big on COVID-19 Candidate, But Ignores Its Own Ivermectin Product. TrialSite News 14.2.2021 (trialsitenews.com).
  • Large Dominican Real World Observational Study with Compassionate Ivermectin Use Points to Strong Efficacy Signal. TrialSite News 14.2.2021 (trialsitenews.com).
  • Catherine Offord: Frontiers Removes Controversial Ivermectin Paper Pre-Publication. The Scientist 2.3.2021 (www.the-scientist.com).
  • Two Groups Review Evidence for Ivermectin Very Differently. TrialSite News 4.3.2021 (trialsitenews.com).
  • Lehtinen, Ilja: Lääke joka katosi. 30.4.2021 (iljalehtinen.medium.com).

MATH+

  • Busby, Mattha: Holistic Approaches May Have Reduced Coronavirus Deaths at This London Hospital. Vice 8.10.2020 (www.vice.com).
  • Farkas, Josh: PulmCrit- CITRIS-ALI: Can a secondary endpoint stage a coup d’état? Emcrit.org 1.10.2019 (emcrit.org). Farkas on Vermontin yliopiston tehohoidon ja keuhkosairauksien apulaisprofessori.
  • Do the MATH+: COVID-19 Protocol of Steroids and Vitamin C Divides Experts. Trialsite News 24.6.2020 (www.trialsitenews.com).
  • Small, Taurean: Senate committee explores COVID-19 recommendations from local expert. Spectrum News 1 6.5.2020 (spectrumnews1.com).
  • Kamen, Joyce: “We’ve Cracked the COVID-19 Code.” (And Why No One is Listening.) Medium, 16.4.2020 (medium.com).
  • Kamen, Joyce: The Facts on Why Tens of Thousands of Americans Died Needlessly from COVID19. 31.8.2020 (medium.com).
  • Naley Andersen, Amalie ja Jonsrud Pedersen, Karine: Fortsetter med C-vitaminbehandling. Nærnett.no 27.2.2020 (www.nernett.no).
  • Blok, Camilla: Legene uenige om «mirakelkur». TV2 Nyheter 9.1.2020 (www.tv2.no).

Videoita

I-MASK+ / ivermektiini

  • TrialSite News Roundup: Dr. Tess Lawrie Discusses her Ivermectin Meta-Analysis, the FDA, and Dr. Andrew Hill. 15.3.2021 (youtu.be).
  • Dr. John Campbell: Ivermectin Evidence with Dr Tess Lawrie. 6.3.2021 (youtu.be).
  • Pierre Kory: The Efficacy of Ivermectin Against COVID‑19. Jan 27, 2021 (covid19criticalcare.com).
  • Dr. Tess Lawrie's systematic review. 25.1.2021 (youtu.be).
  • NIAID Advisory Council Meeting - January 2021. National Institute of Allergy and Infectious Diseases, 25.1.2021 (videocast.nih.gov). Dr. Anthony S. Fauci addresses the full council.
  • Ivermectin meta-analysis by Dr. Andrew Hill. 27.12.2020 (youtu.be). WHO:n meta-analyysista.
  • Fusion Healthcare Webinar: COVID-19, Vitamin C and I-MASK. Paul Marik and Deepak Govil (India). 23.12.2020 (youtu.be).
  • Ivermectin - A Game Changer for COVID-19? Christy Risinger. 22.12.2020 (youtu.be).
  • COVID-19 Learn how to PROTECT YOURSELF as our Hospitals are Brought to their Knees. Jennifer Hibberd. 20.12.2020 (youtu.be).
  • Ivermectin and COVID 19. John Campbell. 12.12.2020 (youtu.be).
  • Dr. Pierre Kory (FLCCC Alliance) testifies to senate committee about I-MASK+ (incl. the following Q&A part). 8.12.2020 (vimeo.com).
  • FLCCC Alliance News Conference: Medical Evidence of Ivermectin— Effectively Prevent & Treat COVID19. 4.12.2020 (youtu.be).
  • Drbeen Medical Lectures: Dr. Paul Marik Discusses His I-MASK+ Protocol. 24.11.2020. (youtu.be).
  • Clinical Trials and Research News Weekly Roundup | I-MASK+: Ivermectin Key For Early Treatment. TrialSite News 16.11.2020 (youtu.be).
  • Dehgani-Mobaraki, Puya and Kory, Pierre: Review of the Emerging Evidence For Use of Ivermectin in the Prophylaxis and Treatment of COVID. Associazione Naso Sano Provider ECM, Nov 14, 2020 (youtu.be).
  • FLCCC Alliance: I-MASK+. 10.11.2020 (vimeo.com). Suurelle yleisölle suunnattu johdanto.
  • Whiteboard Doctor: Interview With Dr. Hector Carvallo: Pioneer In Ivermectin, Iota Carrageenan, Bromhexine And COVID-19. 5.11.2020 (youtu.be).
  • Pierre Kory (FLCCC Alliance) on the importance of Ivermectin in the treatment of COVID-19. 30.10.2020 (vimeo.com).
  • Marik, Paul: COVID 19: Ivermectin Update. 27.10.2020 (youtu.be).
  • TrialSite News: Clinical Trials and Research News Weekly Roundup | Ivermectin Treatment in Three Brazilian Towns. 28.9.2020 (youtu.be).
  • Tratamiento Temprano: Preview of study ivermectin antiviral effectiveness Argentina. 19.9.2020 (youtu.be).
  • Clinical Trials and Research News Weekly Roundup | Zagazig University Ivermectin VS COVID-19. TrialSite News 7.9.2020 (youtu.be).
  • Drbeen Medical Lectures: An Ivermectin Prophylaxis Study From India. 5.11.2020. (youtu.be).
  • Drbeen Medical Lectures: Good News Ivermectin Reduces Mortality In COVID-19 Patients. 4.11.2020. (youtu.be).
  • Drbeen Medical Lectures: Ivermectin Works For COVID-19 - Latest studies. 19.10.2020. (youtu.be).
  • Drbeen Medical Lectures: Ivermectin, Abbott, Dogs, ICM Protocol. 26.9.2020 (youtu.be).
  • TrialSite News Original: Documentary in Peru about Ivermectin and COVID-19. TrialSite News 14.8.2020 (trialsitenews.com).
  • Clinical Trials and Research News Weekly Roundup | S2 E27 | Ivermectin VS Hydroxychloroquine. TrialSite News, 6.7.2020 (youtu.be).
  • Dr. Weller: IVERMECTINA COVID 19. May 17, 2020 (youtu.be).
  • Christy Chrisinger: Ivermectin for the Treatment of COVID - UPDATE 1/20/2021. 20.1.2021 (youtu.be).
  • TratamientoTemprano: WHO Ivermectin news in next 6 weeks. 15 Feb 15, 2021 (youtu.be). Dr. Sylvie Briand and Dr. Maria Van Kerkhove (technical lead for COVID-19)

MATH+

  • Marik, Paul: COVID 19: A Clinical Update. 17.10.2020 (youtu.be).
  • Paul Marik's YouTube channel (www.youtube.com).
  • U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: How New Information Should Drive Policy (www.hsgac.senate.gov).
  • Drbeen Medical Lectures: COVID-19 Management With Dr. Paul Marik - Author Of MATH+ Protocol. 15.9.2020 (youtu.be).
  • Drbeen Medical Lectures: COVID-19 Patient Management with Dr. Paul Marik (Author of MATH+ Protocol). 15.7.2020 (youtu.be).
  • US National Institute of Health (NIH) Speaker Series Webinar: The role of vitamin C in the treatment and prevention of COVID-19. Richard Cheng (MD, PhD). 8.4.2020 (youtu.be).
  • Meet the "Covid Hunter" of Houston. BBC News, 29.7.2020 (www.bbc.com). Dr Joseph Varon is the Chief of Critical Care at UMMC Houston. He says he has adapted a treatment protocol that has given his Covid-19 patients a 95% chance of recovery.

Podcasteja

  • Dr. Pierre Kory Talks Covid-19, Ivermectin and the FLCCC | Podcast E43. TrialSite News, 25.11.2020 (www.trialsitenews.com).
  • Charles Adler Tonight: Ivermectin as a potential covid therapeutic. Nov 18, 2020 (omny.fm).
  • Alan Cannell talks COVID-19: Nobody Likes Cheap Solutions | Podcast S2 E41. TrialSite News, 11.11.2020 (www.trialsitenews.com).

Sivustoja

  • COVID-19 studies for ivermectin (c19ivermectin.com).
  • The COVID-NMA initiative: a living mapping and living systematic review of Covid-19 trials (covid-nma.com).
  • TrialSite News: Ivermectin (trialsitenews.com).
  • Twitter: Dr Andrew Hill (twitter.com). Author of the WHO related meta-analysis
  • USA:n National Institute of Health:n ivermektiinilinjaus 14.1.2021 (www.covid19treatmentguidelines.nih.gov).
  • USA:n National Institute of Health:n ivermektiinilinjaus 27.8.2020 ().
  • ECDC:n maakohtaiset katsaukset (covid19-country-overviews.ecdc.europa.eu).
  • Perun valtion avoin data: COVID-19 -tilastotiedot (www.datosabiertos.gob.pe).
  • icumonitoring.ch (icumonitoring.ch). Sveitsin tehohoidon resurssitilanteen seuranta.
  • Frontline COVID-19 Critical Care Alliancen Facebook-sivu (www.facebook.com).
  • Lucy Kerr: Alguns esclarecimentos sobre a ivermectina (portallucykerr.com). "taxi24hs on Nov 4, 2020 at 9:05 am: Here in Brasil, two city mayors (Itajaí and Natal), who are also medical doctors, made ivermectin available to citizens, at no cost. To get the drug, the person has to get registered in the health system. This data is shared with the local university. Imagine the value of this wealthy data (thousands of patients) to present and future studies about the benefits of this drug. A medical doctor, image diagnosis expert, Dr. Lucy Kerr, leads a 570 medical doctors team. This team is treating patients with ivermectin, both in prevention care and already sick patients. This team has developed protocols which are based on ivermectin. Her site (in portuguese).
  • Reddit: r/ivermectin (www.reddit.com).
  • Reddit: r/covidlonghaulinfo/ (www.reddit.com).
  • PeakProsperity on ivermectin, 29.12.2020 (www.peakprosperity.com).
  • A reddit discussion on FDA and ivermectin. 2.1.2021 (www.reddit.com).
  • Ivermectin vs. COVID-19 blog / list of news (thefoolishnessofgod.blogspot.com).
  • PubChem: Ivermectin (pubchem.ncbi.nlm.nih.gov).
  • Covexit.com: Ivermectin (covexit.com).
  • COVID-19 Related Clinical Studies Spreadsheet (aact.ctti-clinicaltrials.org).
  • Uttar Pradesh COVID-19 Tracker (www.bing.com).
  • Twitter: Juan Chamie (twitter.com).
  • Information in French (ivermectine-covid.ch).
  • Virolaisen ryhmän sivusto (www.koroonateave.ee).

FLCCC-metodit Euroopassa

  • Eivind Hustad Vinjevoll, Volda, Norja (www.facebook.com). Teho-osaston ylilääkäri, Voldan sairaala, Norja
  • Scott Mitchell, Princess Elizabeth Hospital, Guernsey, UK (www.linkedin.com). MRCS, Associate Specialist Emergency Medicine
  • Rolf Ensner, Kantonsspital Aarau, Sveitsi (www.ksa.ch).
  • Puya Dehgani-Mobaraki, Gubbio-Gualdo Tadino Hospital, Italia (puyadehgani.com).
  • Francesco Savelli, ER & Emergency Medicine Hospital of Faenza, Italia (www.auslromagna.it). Pronto Soccorso e Medicina d’Urgenza Ospedale per gli Infermi di Faenza
  • Fabrizio Pedrabissi, Finale Emilia, Italia ().
  • Marco Confalonieri, Professor of Medicine, University of Trieste ().
  • Markus Hell, Paracelsus Medical University, Salzburg, Austria ().
  • Gregor Zasmeta, Krankenhaus der Barmherzigen Brueder Wien, Vienna, Austria ().
  • Jose Luis Diaz-Penalver Gonzalez, Institut Catala Salut, Catalonia, Spain ().
  • Peer Schleyerbach, Arlesheim, Switzerland ().
  • Bettina Schleyerbach, Arlesheim, Switzerland ().
  • Paul Robert Vogt, University Hospital/Zurich, Zurich, Switzerland ().
  • Artur Bartosik, Krakow, Poland ().
  • George P. Chrousos, Professor of Pediatrics and Endocrinology, Holder of the UNESCO Chair on Adolescent Health Care at the University of Athens, Greece ().
  • Franz Brettner, Senior Physician, Head of Department, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
  • Werner Appelt, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, pain medicine, palliative care, Barmherzige Brüder Hospital, Munich, Germany ().
  • Florian Brettner, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
  • Tina Peers, United Kingdom, Surrey, London ().
  • Leonardo Reyes Ortiz, Hospital CIMA, Barcelona, Spain ().
  • Artur Bartosik, Krakow, Poland ().
  • Tomasz Zawada, Wroclaw, Poland ().
  • Tijana Cer Stoja, Emergency Service Novi Sad, Serbia ().
  • Pavol Torok, Clinic AIM, East Slovakian Institute of Cardiovascular Diseases, Kosice, Slovakia ().
  • Arber Hoti, University of Pristina, Kosovo ().
  • Mereu Giovanni Antonio, Cagliari, Italy ().
  • Simon Rauch, Intensive Care Unit, Merano Hospital, Italy ().
  • Francesco Raggi, Terni, Italy ().
  • Plino Calligaro, Villafranca di Verona, Italy ().
  • Zsuzsanna Rago, Albert Szent-Gyorgyi Clinical Center of Szeged University, Hungary ().
  • Theodoros Aslandis, St. Paul General Hospital, Thessaloniki, Greece ().
  • Patrick Jeanmougin, Strasbourg, France ().
  • Matthias Judex, Talissieu, France ().
  • Michal Rezek, St. Anne University Hospital, Brno, Czech Republic ().
  • Nikolay Uvaliev, Acibadem City Clinic - University Hospital Sofia, Bulgaria ().

MATH+ -menetelmän historiasta

Alkuvaiheessa menetelmän käyttöönottoa haittasi WHO:n ohjeistus glukokortikoidien välttämisestä. WHO muutti ohjeistustaan vasta syyskuussa 2020.

  • The FLCCC Alliance Story (covid19criticalcare.com).
  • World Health Organization: WHO updates clinical care guidance with corticosteroid recommendations. 2.9.2020 (www.who.int).
  • U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: Testimony of Pierre Kory, M.D., M.P.A., Critical Care Service Chief, Associate Professor of Medicine, University of Wisconsin School of Medicine and Public Health (www.hsgac.senate.gov). Yhdysvaltojen senaatille 6.5.2020 esitetty materiaali.

Organisaatioita

  • Front Line Covid-19 Critical Care Alliance (covid19criticalcare.com). Tehohoitoasiantuntijoiden yhteenliittymä, joka edistää MATH+ -menetelmän käyttöä.

Contact information: info _ covidcare fi

Treatment of COVID-19 with ivermectin (I-MASK+ protocol)

Introduction

A brief review

A timeline of events

Additional materials

  • A timeline of correspondence with medical doctors, health officials, researchers and politicians (covidcare.fi).
  • A response to request VN/24131/2020 of the Ministry of Health. Nov 12, 2020 (covidcare.fi).
  • A proposal to national health technology assesment process (FinCCHTA): I-MASK+. Nov 16, 2020 (covidcare.fi).
  • A proposal to national health technology assesment process (FinCCHTA): MATH+. Nov 16, 2020 (covidcare.fi).

Meta-analysis (@CovidAnalysis/ivmmeta.com group)

  • Ivermectin is effective for COVID-19: real-time meta analysis (ivmmeta.com).
  • An up-to-date list of completed clinical trials (c19ivermectin.com).
  • Global ivermectin adoption for COVID-19 (status report) (ivmstatus.com). As of March 2021, in Europe, ivermectin is officially adopted for COVID-19 in Slovakia and Czech Republic.
  • Ivermectin is effective for COVID-19: meta analysis of 52 studies. Apr 30, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 46 studies. Mar 17, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 43 studies. Mar 4, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 41 studies. Feb 18, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 35 studies. Jan 20, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 32 studies. Jan 13, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 28 studies. Jan 2, 2021 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 26 studies. Dec 18, 2020 (covidcare.fi).
  • Ivermectin is effective for COVID-19: meta analysis of 21 studies. Nov 26, 2020 (covidcare.fi).
  • An estimate of the number of unnecessary deaths (c19legacy.com).

The FLCCC Alliance treatment protocols

I-MASK+ / Ivermectin

  • One-page summary of the review on ivermectin in COVID-19 (covid19criticalcare.com).
  • In-depth description of the I-MASK+ protocol (covid19criticalcare.com). An in-depth research review.
  • Ivermectin — a potential global solution to the pandemic (covid19criticalcare.com). A summary of research.
  • I-MASK+ protocol (covid19criticalcare.com). A general description.
  • Paul E. Marik: COVID-19 Rx Meta-analysis, Nov 25, 2020 (covidcare.fi).
  • FAQ on ivermectin (covid19criticalcare.com).
  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. American Journal of Therapeutics 2021. doi: 10.1097/MJT.0000000000001377 (journals.lww.com).

MATH+

  • Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org). A description of the MATH+ method as a peer-reviewed journal publication.
  • Scientific Review of COVID-19 and MATH+ (covid19criticalcare.com). A description of the rationale behind the protocol.
  • MATH+ and translations (covid19criticalcare.com). General description of MATH+ protocol.
  • Eastern Virginia Medical School: COVID Care Protocol for Clinicians (www.evms.edu). A more often updated, "original" version of the protocol. Ivermectin has been an optional component since May 11, 2020 but since October 29, 2020 it has been an essential component.

Development team

Professor Marik has published over 400 academic journal articles and numerous other publications. His h index is 93 and he has over 33700 citations. Professor Gianfranco Umberto Meduri’s h index is 66 with 19100 citations. Professor Joseph Varon has a h index of 45 with 9100 citations. Associate professor Pierre Kory has a h index of 16 with nearly 1000 citations. Associate professor Jose Iglesias has a h index of 15 with over 700 citations. The team also includes additional members.

Academic publications and clinical trials

The list reflects the situation on Dec 1, 2020. See also a comprehensive timeline of ivermectin trials at c19ivermectin.com and a meta-analysis at ivmmeta.com. However, this section contains ivermectin reviews and theory articles and MATH+ articles that are not available on those websites.

Ivermectin: prophylaxis RCTs

  • Shouman W et.al: Prophylactic Ivermectin in COVID-19 Contacts. NCT04422561. Aug 27, 2020 (clinicaltrials.gov). 7% infected vs 58% in the control group.
  • Carvallo HE et.al.: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR). NCT04425850. Oct 19, 2020 (clinicaltrials.gov). 0% infected vs 11% in the control group.
  • Behera P, Patro BK, Singh AK, et al.: Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study. Nov 3, 2020 (doi.org). 73% reduction in infections.
  • Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. Nov 16, 2020 (doi.org). 2% infected vs 10% in the control group.

Ivermectin: hospital RCTs

  • Mahmud R. et.al.: Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection (NCT04523831) (clinicaltrials.gov). Results: early clinical improvement: 60% vs 44%; late clinical improvement: 23% vs 37%; clinical deterioration: 8% vs 18%; persistently RT-PCR positive: 8% vs 20%; adverse events: 2 vs 0; deaths: 0 vs 3
  • Hashim HA, Maulood MF, Rasheed AM, Fatak DF, Kabah KK, Abdulamir AS: Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq (NCT04591600). medRxiv, Oct 27, 2020 (www.medrxiv.org). reduced mortality, reduced time to recovery.
  • Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. Nov 16, 2020 (doi.org). 90 % reduction in mortality; shorter hospital stays.
  • Niaee MS, Gheibi N, Namdar P, Allami A, Zolghadr L, Javadi A, Karampour A, Varnaseri M, Bizhani B, Cheraghi F, Naderi Y, Amini F, Karamyan M, Yadyad MJ, Jamshidian R: Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial. Research Square, Nov 24, 2020 (doi.org). 82% lower mortality.
  • Krolewiecki, Alejandro and Lifschitz, Adrián and Moragas, Matías and Travacio, Marina and Valentini, Ricardo and Alonso, Daniel F. and Solari, Rubén and Tinelli, Marcelo Adrián and Cimino, Ruben Oscar and Álvarez, Luis and Fleitas, Pedro Emanuel and Ceballos, Laura and Golemba, Marcelo Darío and Fernández, Florencia and Fernández de Oliveira, Diego and Astudillo, Germán and Baeck, Inés and Farina, Javier and Guthmann, Marcelo David and Cardama, Georgina A. and Mangano, Andrea and Spitzer, Eduardo and Gold, Silvia and Lanusse, Carlos, Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial. SSRN Electronic Journal 2020. (doi.org). significantly lower viral load in patients with higher plasma ivermectin levels.

Ivermectin: retrospective and observational studies

  • Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter J-J: Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019. Chest 2020 (doi.org). mortality 13% vs 25%.
  • Hellwig MD, Maia A: A COVID-19 Prophylaxis? Lower incidence associated with prophylactic administration of Ivermectin. International Journal of Antimicrobial Agents 2020;106248 (doi.org). 80% less infections.
  • Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O: Bénéfice de l’ivermectine : de la gale à la COVID-19, un exemple de sérendipité. Annales de Dermatologie et de Vénéréologie 2020;147(12):A194 (doi.org). 0% vs 5% mortality, 0% vs 22.6% serious disease.
  • Guerrero R, Bravo L, Muñoz E, Grillo Ardila E, Guerrero E: COVID-19: The Ivermectin African Enigma. Colombia Médica 2020;51(4):e-2014613 (colombiamedica.univalle.edu.co).
  • Brian C. Procter, Casey Ross, Vanessa Pickard, Erica Smith, Cortney Hanson, Peter A. McCullough. Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection. Reviews in Cardiovascular Medicine 2020;21(4):611–4 (doi.org).

Ivermectin: prolonged / post-acute COVID-19 syndrome

  • Aguirre Chang G, Saavedra E, Yui Cerna M, Trujillo Figueredo A, Córdova Masías JA: Post-acute or prolonged COVID-19: Treatment with ivermectin for patients with persistent or post-acute symptoms. ResearchGate 2020 (www.researchgate.net).

Ivermectin: reviews, epidemiology and theory

  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. Front Pharmacol 2021. doi: 10.3389/fphar.2021.643369 (web.archive.org).
  • Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19. OSF Preprints 2020 (osf.io).
  • Andrew Hill, Ahmed Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn McCann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel: Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection. Research Square 19.1.2021 (doi.org). The "WHO meta-analysis"
  • Scheim D: Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion. SSRN Electronic Journal, Jun 26, 2020 (doi.org).
  • Chamie J: Real-World Evidence: The Case of Peru. Causality between Ivermectin and COVID-19 Infection Fatality Rate. 2020 (www.researchgate.net).
  • Pandey S, Pathak SK, Pandey A, Salunke AA, Chawla J, Sharma A, Sharma S, Thivari P, Ratha HVK: Ivermectin in COVID-19: What do we know? Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2020;14(6):1921-2. (doi.org).
  • Sparavigna AC: Ivermectin for Covid-19. Working paper. Zenodo, Sep 20, 2020 (doi.org).
  • Elkholy KO, Hegazy O, Erdinc B, Abowali H: Ivermectin: A Closer Look at a Potential Remedy. Cureus 2020. (doi.org).
  • Scheim D: Antimalarials for COVID-19 Treatment: Rapid Reversal of Oxygen Status Decline with the Nobel Prize-Honored Macrocyclic Lactone Ivermectin. SSRN Electronic Journal, Jun 3, 2020 (doi.org).
  • Rizzo E: Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. Naunyn Schmiedebergs Arch Pharmacol 2020 May 27: 1–4. PMC7251046 (doi.org).
  • Morgenstern J, Redondo JN, De León A, Canela JM, Torres N, Tavares J, Minaya M, López Ó, Plácido AM, Castillo A, Peña Cruz R, Merette Y, Toribio M, Francisco JA, Roca S: The use of compassionate Ivermectin in the management of symptomatic outpatients and hospitalized patients with clinical diagnosis of COVID-19 at the Medical Center Bournigal and the Medical Center Punta Cana, Rescue Group, Dominican Republic, from may 1 to august 10, 2020. medRxiv 2020.10.29.20222505. Nov 3, 2020 (doi.org).
  • Parth Sarthi Sen Gupta and Satyaranjan Biswal and Saroj Kumar Panda and Abhik Kumar Ray and Malay Kumar Rana: Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin. Journal of Biomolecular Structure and Dynamics 2020 (doi.org).
  • Lawrie T: Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance. E-BMC Ltd, Jan 3, 2021 (bit.ly).
  • McCullough PA, Alexander PE, Armstrong R, Arvinte C, Bain AF, Bartlett RP, et al.: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine 2020;21(4):517-530 (doi.org).
  • Ramírez, Céleo et al.: Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis? Lancet EClinicalMedicine, 100744, Feb 4, 2021 (doi.org).

MATH+

  • Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org).
  • Marik PE, Kory P, Varon J, Iglesias J, Meduri GU. MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale. Expert Rev Anti Infect Ther 2020;18:1-7. doi: 10.1080/14787210.2020.1808462. PMID: 32809870 (covid19criticalcare.com).
  • Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H, Peng Z-Y: Pilot Trial of High-dose vitamin C in critically ill COVID-19 patients. Preprint. Research Square, Sep 23, 2020 (doi.org).
  • Kory P, Kanne JP: SARS-CoV-2 organising pneumonia: Has there been a widespread failure to identify and treat this prevalent condition in COVID-19? BMJ Open Respiratory Research 2020;7:e000724 (doi.org). Explains the 'happy hypoxia'.
  • Arvinte C, Singh M, Marik PE: Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020. A pilot study. Medicine in drug discovery 2020 (doi.org). This pilot study found low serum levels of vitamin C and vitamin D in most of the critically ill COVID-19 ICU patients. Older age and low vitamin C level appeared co-dependent risk factors for mortality.
  • Chiscano-Camón L, Ruiz-Rodriguez J, Ruiz-Sanmartin A et al.: Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care 2020;24:522 (doi.org).
  • Honore PM, Spapen HD, Marik PE et. al.: Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care 2020;10:23 (doi.org).
  • Jovic TH, Ali SR, Ibrahim N, Jessop ZM, Tarassoli SP, Dobbs TD, Holford P, Thornton CA, Whitaker IS: Could Vitamins Help in the Fight Against COVID-19? Nutrients 2020;12:2550 (doi.org).
  • Marik PE, Payen D: CITRIS-ALI: How statistics were used to obfuscate the true findings. Anaesthesia Critical Care & Pain Medicine 2019;38(6):575–577. Doi: 10.1016/j.accpm.2019.10.004 (www.researchgate.net).
  • Fowler AA, Fisher BJ, Kashiouris MG: Vitamin C for Sepsis and Acute Respiratory Failure. JAMA 2020;323(8):792–3 (doi.org). A methodical correction to CITRIS-ALI study, resulting in mSOFA score becoming statistically significant at 96 hours.
  • Frommelt MA, Kory P, Long MT: Letter on Update to the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Protocol. Trials 2020;21:350 (doi.org).
  • Fowler AA, Syed AA, Knowlson S et. al.: Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014;12:32 (doi.org). Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
  • Mao E: Intensive management of severe acute pancreatitis. Annals of Translational Medicine 2019;7(22) (atm.amegroups.com). High-dose intravenous vitamin C has been routinely used for various conditions in some intensive care units in China for a decade.
  • Hemilä H, Chalker E: Vitamin C as a Possible Therapy for COVID-19. Infection & Chemotherapy 2020;52(2):222-223 (doi.org).

News and blog articles

I-MASK+ / Ivermectin

  • How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru. TrialSite News, Jun 6, 2020 (www.trialsitenews.com).
  • Well-Respected Australian Researcher: Consider Triple Therapy (Ivermectin, Zinc, Doxycycline) for COVID-19. TrialSite News, Aug 4, 2020 (www.trialsitenews.com).
  • Australian GPs Can Legally Prescribe Ivermectin Triple Therapy Protocol — Professor Thomas Borody. Aug 19, 2020 (covexit.com).
  • Argentina’s IVERCAR Ivermectin & Carrageenan Study Shows Positive Results Targeting COVID-19. TrialSite News, Sep 3, 2020 (www.trialsitenews.com).
  • An Old Drug Tackles New Tricks: Ivermectin Treatment in Three Brazilian Towns. TrialSite News, Sep 16, 2020 (www.trialsitenews.com).
  • Ivermectin Works and Should be Accepted for Large Observational Studies. Trialsite News, Oct 28, 2020 (www.trialsitenews.com).
  • Real World Evidence? I-MASK+ Protocol: Ivermectin Key for Prophylaxis and Early Treatment of COVID-19. TrialSite News, Nov 3, 2020 (www.trialsitenews.com).
  • Benha University Breakthrough: Randomized Controlled Trial Shows Ivermectin Effective for Treating COVID-19 & as Prophylaxis. TrialSite News, Nov 14, 2020 (www.trialsitenews.com).
  • Why Isn’t Ivermectin Being Widely Researched and Utilized? TrialSite News, Nov 15, 2020 (www.trialsitenews.com).
  • Joseph A. Ladapo: Too Much Caution Is Killing Covid Patients. Doctors should follow the evidence for promising therapies. Instead they demand certainty. Wall Street Journal, Nov 24, 2020 (www.wsj.com).
  • Carvallo H. et.al.: Resultados positivos del protocolo IVER.CAR en la profilaxis de los agentes de salud. 2020 (www.pharmabaires.com).
  • ICDDR Dhaka Bangladesh Completes Successful Ivermectin Clinical Trial. TrialSite News, Dec 9, 2020 (trialsitenews.com).
  • US Senate Hearing Explores Ivermectin as “Miracle Drug” for COVID-19 While Mainstream Media Outlets Ignore. TrialSite News, Dec 11, 2020 (trialsitenews.com).
  • Introducing the Physicians for Civil Defense: Prominent Doctors Know Ivermectin can Help Treat COVID-19: Will Anyone Listen? TrialSite News, Dec 11, 2020 (trialsitenews.com).
  • Beyond The Roundup | Senate Hearing On Ivermectin Brings Unexpected Drama. TrialSite News, Dec 12, 2020 (trialsitenews.com).
  • Fact Checking the Fact Checkers: The Case of Ivermectin for Publicly-Subsidized Research. TrialSite News, Dec 13, 2020 (trialsitenews.com).
  • Interview with Lawyer Jean-Charles Teissedre about Ivermectin. Covexit, Dec 13, 2020 (covexit.com).
  • Clinical Trials and Research Roundup | Doctors: Ivermectin Can Help Treat COVID: Will Anyone Listen?. TrialSite News, Dec 14, 2020 (trialsitenews.com).
  • Prasad, Amit Mohan: From control rooms to testing, several strategies helped UP contain pandemic. The Indian Express Dec 17, 2020 (indianexpress.com). Uttar Pradesh has distributed ivermectin for prophylaxis since July, and ivermectin and doxycycline has been used by hospitals.
  • Bangladesh Medical College Observational Study: Ivermectin Works as PrEP for Health Care Workers Against COVID-19. TrialSite News, Dec 17, 2020 (trialsitenews.com).
  • Webinar with Professor Paul Marik: the Prevention & Outpatient Treatment of C19. Covexit, Dec 17, 2020 (covexit.com).
  • MedinCell’s Mission for ‘Mass Roll-out’ of Ivermectin for COVID-19: Early Study Data Points Reveal Promise. TrialSite News, Dec 18, 2020 (trialsitenews.com).
  • Ivermectin Shows Potential as a Promising COVID-19 Prophylactic According to Study Published in Peer-Review Journal. TrialSite News, Dec 19, 2020 (trialsitenews.com).
  • Ivermectin to Save Belgium? Covexit, Dec 22, 2020 (covexit.com).
  • MALMED will approve Ivermectin, but then will ask the pharmaceutical companies to bring it because "it is not a cure for business". Dec 24, 2020 (www.slobodenpecat.mk).
  • Bulgarian Prof. Ivo Petrov: Ivermectin Plays The Role of A Live Vaccine. Dec 24, 2020 (www.novinite.com).
  • Did you Hear about the ZIVERDO Therapy for COVID-19? Covexit, Dec 26, 2020 (covexit.com).
  • Mary Beth Pfeiffer: In Far-Flung Places, COVID-19 Is Being Treated Early And Well. Here’s Why Americans Don’t Know This. TrialSite News 27.12.2020 (trialsitenews.com).
  • Macedonia Nears Approval of Ivermectin for COVID-19 as Word of the Drug Spreads in the Balkan Peninsula. TrialSite News, Dec 28, 2020 (trialsitenews.com).
  • Unitaid, Part of the World Health Organization Funding Ivermectin Research Targeting COVID-19 led by British Expert. TrialSite News, Dec 29, 2020 (trialsitenews.com).
  • Can Ivermectin be used to treat COVID-19 (coronavirus)? Drugs.com, Dec 29, 2020 (www.drugs.com).
  • Beyond The Roundup | Central American Nation of Belize Authorizes Use of Ivermectin for COVID-19. TrialSite News, Dec 30, 2020 (trialsitenews.com).
  • Prof. Ivo Petrov for Ivermectin: The Study Is Over, The Results Are Encouraging. Dec 31, 2020 (www.novinite.com).
  • WHO-sponsored preliminary review indicates Ivermectin effectiveness. Dec 31, 2020 (swprs.org).
  • Paul E. Sax: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? NEJM Journal Watch, Jan 4, 2021 (blogs.jwatch.org).
  • NIH COVID-19 Treatment Guidelines Panel Invites Top Ivermectin Researchers to Discuss the Evidence of Efficacy to Date. Jan 8, 2020 (trialsitenews.com).
  • Growing Momentum for Ivermectin in German Press as Pharmacy Journal Introduces Ivermectin as Possible Treatment for COVID-19. TrialSite News, Jan 17, 2021 (trialsitenews.com).
  • Barcelona Institute for Global Health (ISGlobal): A clinical trial provides encouraging results on ivermectin for reducing mild COVID-19. Jan 19, 2021 (www.eurekalert.org).
  • Donato Paolo Mancini: Cheap antiparasitic could cut chance of Covid-19 deaths by up to 75%. Financial Times, Jan 20, 2021 (www.ft.com).
  • Spanish Pilot Study Reveals Ivermectin Can Possibly Reduce Viral Transmission. TrialSite News, Jan 21, 2021 (trialsitenews.com).
  • Rhys Blakely: Trial for Covid ‘wonder drug’ that could save thousands of lives. The Times (UK), Jan 23, 2021 (www.thetimes.co.uk).
  • Ministério Público Federal (Brazil): Covid-19: Conselho Federal de Medicina ressalta autonomia do médico e do paciente na utilização de medicamentos e procedimentos. 23.1.2021 (www.mpf.mp.br). physicians are officially allowed autonomous decisions regarding treatment of COVID-19 patients.
  • Financial Times Adds to Argument for Ivermectin. TrialSite News, Jan 23, 2021 (trialsitenews.com).
  • Oxford’s PRINCIPLE Trial: Bringing Ivermectin Directly into the Developed World in the Battle Against COVID-19. TrialSite News, Jan 23, 2021 (trialsitenews.com).
  • Jackie Cameron: Ivermectin: Major tech breakthrough in human application, as scientists aim to save world from Covid-19 and malaria. Feb 11, 2021 (www.biznews.com).
  • Belgian Virologist Proposes a Plan to Eradicate COVID-19 in 6 Weeks Using Ivermectin. TrialSite News, Feb 13, 2021 (trialsitenews.com).
  • Beyond The Roundup | Bill and Melinda Gates Fund Global Ivermectin Clinical Trial. TrialSite News, Feb 13, 2021 (trialsitenews.com).
  • Merck Spends Big on COVID-19 Candidate, But Ignores Its Own Ivermectin Product. TrialSite News, Feb 14, 2021 (trialsitenews.com).
  • Large Dominican Real World Observational Study with Compassionate Ivermectin Use Points to Strong Efficacy Signal. TrialSite News, Feb 14, 2021 (trialsitenews.com).
  • Catherine Offord: Frontiers Removes Controversial Ivermectin Paper Pre-Publication. The Scientist, Mar 2, 2021 (www.the-scientist.com).
  • Two Groups Review Evidence for Ivermectin Very Differently. TrialSite News, Mar 4, 2021 (trialsitenews.com).
  • Lehtinen, Ilja: Lääke joka katosi [The medicine which disappeared (a review in Finnish)]. Apr 30, 2021 (iljalehtinen.medium.com).

MATH+

  • Busby, Mattha: Holistic Approaches May Have Reduced Coronavirus Deaths at This London Hospital. Vice, Oct 8, 2020 (www.vice.com).
  • Farkas, Josh: PulmCrit- CITRIS-ALI: Can a secondary endpoint stage a coup d’état? Emcrit.org, Oct 1, 2019 (emcrit.org). Farkas is an associate professor of Pulmonary and Critical Care Medicine at the University of Vermont.
  • Do the MATH+: COVID-19 Protocol of Steroids and Vitamin C Divides Experts. Trialsite News, Jul 24, 2020 (www.trialsitenews.com).
  • Small, Taurean: Senate committee explores COVID-19 recommendations from local expert. Spectrum News 1, May 6, 2020 (spectrumnews1.com).
  • Kamen, Joyce: “We’ve Cracked the COVID-19 Code.” (And Why No One is Listening.) Medium, Apr 16th, 2020 (medium.com).
  • Kamen, Joyce: The Facts on Why Tens of Thousands of Americans Died Needlessly from COVID19. Aug 31, 2020 (medium.com).
  • Naley Andersen, Amalie ja Jonsrud Pedersen, Karine: Fortsetter med C-vitaminbehandling. Nærnett.no, Feb 27, 2020 (www.nernett.no).
  • Blok, Camilla: Legene uenige om «mirakelkur». TV2 Nyheter, Jan 1, 2020 (www.tv2.no).

Videos

I-MASK+ / Ivermectin

  • TrialSite News Roundup: Dr. Tess Lawrie Discusses her Ivermectin Meta-Analysis, the FDA, and Dr. Andrew Hill. March 15, 2021 (youtu.be).
  • Dr. John Campbell: Ivermectin Evidence with Dr Tess Lawrie. March 6, 2021 (youtu.be).
  • Pierre Kory: The Efficacy of Ivermectin Against COVID‑19. Jan 27, 2021 (covid19criticalcare.com).
  • Dr. Tess Lawrie's systematic review. Jan 25, 2021 (youtu.be).
  • NIAID Advisory Council Meeting - January 2021. National Institute of Allergy and Infectious Diseases, Jan 25, 2021 (videocast.nih.gov). Dr. Anthony S. Fauci addresses the full council.
  • Ivermectin meta-analysis by Dr. Andrew Hill. Dec 27, 2020 (youtu.be). about the WHO meta-analysis.
  • Fusion Healthcare Webinar: COVID-19, Vitamin C and I-MASK. Paul Marik and Deepak Govil (India). Dec 23, 2020 (youtu.be).
  • Ivermectin - A Game Changer for COVID-19? Christy Risinger. Dec 22, 2020 (youtu.be).
  • COVID-19 Learn how to PROTECT YOURSELF as our Hospitals are Brought to their Knees. Jennifer Hibberd. Dec 20, 2020 (youtu.be).
  • Ivermectin and COVID 19. John Campbell. Dec 12, 2020 (youtu.be).
  • Dr. Pierre Kory (FLCCC Alliance) testifies to senate committee about I-MASK+ (incl. the following Q&A part). Dec 8, 2020 (vimeo.com).
  • FLCCC Alliance News Conference: Medical Evidence of Ivermectin— Effectively Prevent & Treat COVID19. Dec 4, 2020 (youtu.be).
  • Drbeen Medical Lectures: Dr. Paul Marik Discusses His I-MASK+ Protocol. Nov 24, 2020. (youtu.be).
  • Clinical Trials and Research News Weekly Roundup | I-MASK+: Ivermectin Key For Early Treatment. TrialSite News, Nov 16, 2020 (youtu.be).
  • Kory, Pierre: Review of the Emerging Evidence For Use of Ivermectin in the Prophylaxis and Treatment of COVID. Associazione Naso Sano Provider ECM, Nov 14, 2020 (youtu.be).
  • FLCCC Alliance: I-MASK+. Nov 10, 2020 (vimeo.com). An introduction aimed at the general public.
  • Whiteboard Doctor: Interview With Dr. Hector Carvallo: Pioneer In Ivermectin, Iota Carrageenan, Bromhexine And COVID-19. Nov 5, 2020 (youtu.be).
  • Pierre Kory (FLCCC Alliance) on the importance of Ivermectin in the treatment of COVID-19. Oct 30, 2020 (vimeo.com).
  • Marik, Paul: COVID 19: Ivermectin Update. Oct 27, 2020 (youtu.be).
  • TrialSite News: Clinical Trials and Research News Weekly Roundup | Ivermectin Treatment in Three Brazilian Towns. Sep 28, 2020 (youtu.be).
  • Tratamiento Temprano: Preview of study ivermectin antiviral effectiveness Argentina. Sep 9, 2020 (youtu.be).
  • Clinical Trials and Research News Weekly Roundup | Zagazig University Ivermectin VS COVID-19. TrialSite News Sep 7, 2020 (youtu.be).
  • Drbeen Medical Lectures: An Ivermectin Prophylaxis Study From India. Nov 5, 2020. (youtu.be).
  • Drbeen Medical Lectures: Good News Ivermectin Reduces Mortality In COVID-19 Patients. Nov 4, 2020. (youtu.be).
  • Drbeen Medical Lectures: Ivermectin Works For COVID-19 - Latest studies. Oct 19, 2020. (youtu.be).
  • Drbeen Medical Lectures: Ivermectin, Abbott, Dogs, ICM Protocol. Sep 26, 2020 (youtu.be).
  • TrialSite News Original: Documentary in Peru about Ivermectin and COVID-19. TrialSite News, Aug 14, 2020 (trialsitenews.com).
  • Clinical Trials and Research News Weekly Roundup | S2 E27 | Ivermectin VS Hydroxychloroquine. TrialSite News, Jul 6, 2020 (youtu.be).
  • Dr. Weller: IVERMECTINA COVID 19. May 17, 2020 (youtu.be).
  • Christy Chrisinger: Ivermectin for the Treatment of COVID - UPDATE 1/20/2021. Jan 20, 2021 (youtu.be).
  • TratamientoTemprano: WHO Ivermectin news in next 6 weeks. 15 Feb 15, 2021 (youtu.be). Dr. Sylvie Briand and Dr. Maria Van Kerkhove (technical lead for COVID-19)

MATH+

  • Marik, Paul: COVID 19: A Clinical Update. Oct 17, 2020 (youtu.be).
  • Paul Marik's YouTube channel (www.youtube.com).
  • U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: How New Information Should Drive Policy (www.hsgac.senate.gov).
  • Drbeen Medical Lectures: COVID-19 Management With Dr. Paul Marik - Author Of MATH+ Protocol. Sep 15, 2020 (youtu.be).
  • Drbeen Medical Lectures: COVID-19 Patient Management with Dr. Paul Marik (Author of MATH+ Protocol). Jul 15, 2020 (youtu.be).
  • US National Institute of Health (NIH) Speaker Series Webinar: The role of vitamin C in the treatment and prevention of COVID-19. Richard Cheng (MD, PhD). Apr 8, 2020 (youtu.be).
  • Meet the "Covid Hunter" of Houston. BBC News, Jul 29, 2020 (www.bbc.com). Dr Joseph Varon is the Chief of Critical Care at UMMC Houston. He says he has adapted a treatment protocol that has given his Covid-19 patients a 95% chance of recovery.

Podcasts

  • Dr. Pierre Kory Talks Covid-19, Ivermectin and the FLCCC | Podcast E43. TrialSite News, Nov 25, 2020 (www.trialsitenews.com).
  • Charles Adler Tonight: Ivermectin as a potential covid therapeutic. Nov 18, 2020 (omny.fm).
  • Alan Cannell talks COVID-19: Nobody Likes Cheap Solutions | Podcast S2 E41. TrialSite News, Nov 11, 2020 (www.trialsitenews.com).

Websites

  • COVID-19 studies for ivermectin (c19ivermectin.com).
  • The COVID-NMA initiative: a living mapping and living systematic review of Covid-19 trials (covid-nma.com).
  • TrialSite News: Ivermectin (trialsitenews.com).
  • Twitter: Dr Andrew Hill (twitter.com). Author of the WHO related meta-analysis
  • NIH COVID-19 Treatment Guidelines: Ivermectin. Jan 14, 2021 (www.covid19treatmentguidelines.nih.gov).
  • NIH COVID-19 Treatment Guidelines: Ivermectin. Aug 27, 2020 ().
  • ECDC country overviews (covid19-country-overviews.ecdc.europa.eu).
  • Open data repository of the government of Peru: COVID-19 datasets (www.datosabiertos.gob.pe).
  • icumonitoring.ch (icumonitoring.ch). Near-real time monitoring of intensive care resources in Switzerland.
  • Frontline COVID-19 Critical Care Alliance Facebook Page (www.facebook.com).
  • Lucy Kerr: Alguns esclarecimentos sobre a ivermectina (portallucykerr.com). "taxi24hs on Nov 4, 2020 at 9:05 am: Here in Brasil, two city mayors (Itajaí and Natal), who are also medical doctors, made ivermectin available to citizens, at no cost. To get the drug, the person has to get registered in the health system. This data is shared with the local university. Imagine the value of this wealthy data (thousands of patients) to present and future studies about the benefits of this drug. A medical doctor, image diagnosis expert, Dr. Lucy Kerr, leads a 570 medical doctors team. This team is treating patients with ivermectin, both in prevention care and already sick patients. This team has developed protocols which are based on ivermectin. Her site (in portuguese).
  • Reddit: r/ivermectin (www.reddit.com).
  • Reddit: r/covidlonghaulinfo/ (www.reddit.com).
  • PeakProsperity on ivermectin, Dec 29, 2020 (www.peakprosperity.com).
  • A reddit discussion on FDA and ivermectin. Jan 2, 2021 (www.reddit.com).
  • Ivermectin vs. COVID-19 blog / list of news (thefoolishnessofgod.blogspot.com).
  • PubChem: Ivermectin (pubchem.ncbi.nlm.nih.gov).
  • Covexit.com: Ivermectin (covexit.com).
  • COVID-19 Related Clinical Studies Spreadsheet (aact.ctti-clinicaltrials.org).
  • Uttar Pradesh COVID-19 Tracker (www.bing.com).
  • Twitter: Juan Chamie (twitter.com).
  • Information in French (ivermectine-covid.ch).
  • Website of an Estonian group (www.koroonateave.ee).

FLCCC protocol advocates in Europe

  • Eivind Hustad Vinjevoll, Volda, Norway (www.facebook.com). Senior Consultant Anesthesiologist, Chief of Intensive care and Emergency medicine, Volda Hospital, HMR, Norway
  • Scott Mitchell, Princess Elizabeth Hospital, Guernsey, UK (www.linkedin.com). MRCS, Associate Specialist Emergency Medicine
  • Rolf Ensner, Kantonsspital Aarau, Switzerland (www.ksa.ch).
  • Puya Dehgani-Mobaraki, Gubbio-Gualdo Tadino Hospital, Italy (puyadehgani.com).
  • Francesco Savelli, ER & Emergency Medicine Hospital of Faenza, Italy (www.auslromagna.it). Pronto Soccorso e Medicina d’Urgenza Ospedale per gli Infermi di Faenza
  • Fabrizio Pedrabissi, Finale Emilia, Italy ().
  • Marco Confalonieri, Professor of Medicine, University of Trieste ().
  • Markus Hell, Paracelsus Medical University, Salzburg, Austria ().
  • Gregor Zasmeta, Krankenhaus der Barmherzigen Brueder Wien, Vienna, Austria ().
  • Jose Luis Diaz-Penalver Gonzalez, Institut Catala Salut, Catalonia, Spain ().
  • Peer Schleyerbach, Arlesheim, Switzerland ().
  • Bettina Schleyerbach, Arlesheim, Switzerland ().
  • Paul Robert Vogt, University Hospital/Zurich, Zurich, Switzerland ().
  • Artur Bartosik, Krakow, Poland ().
  • George P. Chrousos, Professor of Pediatrics and Endocrinology, Holder of the UNESCO Chair on Adolescent Health Care at the University of Athens, Greece ().
  • Franz Brettner, Senior Physician, Head of Department, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
  • Werner Appelt, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, pain medicine, palliative care, Barmherzige Brüder Hospital, Munich, Germany ().
  • Florian Brettner, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
  • Tina Peers, United Kingdom, Surrey, London ().
  • Leonardo Reyes Ortiz, Hospital CIMA, Barcelona, Spain ().
  • Artur Bartosik, Krakow, Poland ().
  • Tomasz Zawada, Wroclaw, Poland ().
  • Tijana Cer Stoja, Emergency Service Novi Sad, Serbia ().
  • Pavol Torok, Clinic AIM, East Slovakian Institute of Cardiovascular Diseases, Kosice, Slovakia ().
  • Arber Hoti, University of Pristina, Kosovo ().
  • Mereu Giovanni Antonio, Cagliari, Italy ().
  • Simon Rauch, Intensive Care Unit, Merano Hospital, Italy ().
  • Francesco Raggi, Terni, Italy ().
  • Plino Calligaro, Villafranca di Verona, Italy ().
  • Zsuzsanna Rago, Albert Szent-Gyorgyi Clinical Center of Szeged University, Hungary ().
  • Theodoros Aslandis, St. Paul General Hospital, Thessaloniki, Greece ().
  • Patrick Jeanmougin, Strasbourg, France ().
  • Matthias Judex, Talissieu, France ().
  • Michal Rezek, St. Anne University Hospital, Brno, Czech Republic ().
  • Nikolay Uvaliev, Acibadem City Clinic - University Hospital Sofia, Bulgaria ().

About the history of MATH+ protocol

Initially, adoption of the protocol was hindered by WHO advicing against glucocorticoids. The guidance was changed no earlier than September 2020.

  • The FLCCC Alliance Story (covid19criticalcare.com).
  • World Health Organization: WHO updates clinical care guidance with corticosteroid recommendations. Sep 2, 2020 (www.who.int).
  • U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: Testimony of Pierre Kory, M.D., M.P.A., Critical Care Service Chief, Associate Professor of Medicine, University of Wisconsin School of Medicine and Public Health (www.hsgac.senate.gov). A presentation for the US senate on May 6, 2020.

Organizations

  • Front Line Covid-19 Critical Care Alliance (covid19criticalcare.com). An alliance of intensive care specialists promoting the MATH+ Hospital Treatment protocol.

Contact information: info _ covidcare fi