COVID-19:n hoito ivermektiinillä (I-MASK+ -menetelmä)
- MATH+: sairaala- ja tehohoitoon tarkoitettu menetelmä
- I-MASK+: ivermektiiniin perustuva ennaltaehkäisy-, estohoito- ja avohoitomenetelmä
Johdanto
- MATH+ ja I-MASK+ -menetelmät COVID-19:n hoitoon ja ennaltaehkäisyyn. 2.11.2020.
- Amerikkalainen professoriryhmä esittää hoitoa koronavirussairauteen. 15.11.2020.
- Ivermektiini on vaikuttava COVID-19 -infektiossa. 18.12.2020.
Lyhyt katsaus
- The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19. Cureus 31.12.2020. Doi: 10.7759/cureus.12403
- FLCCC Alliance MATH+ ascorbic acid and I-MASK+ ivermectin protocols for COVID-19 – A Brief Review. Preprint. SSRN Electronic Journal 10.11.2020. Doi: 10.2139/ssrn.3723854
Aikajana
- A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic. 3.4.2021.
- A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic. 24.3.2021 (old version).
Muuta aineistoa
- Muistiinpanoja kirjeenvaihdosta lääkäreiden, viranomaisten, tutkijoiden ja poliitikkojen kanssa (covidcare.fi).
- Vastaus STM:n lausuntopyyntöön (VN/24131/2020). 12.11.2020 (covidcare.fi).
- Ehdotus: FinCCHTA: I-MASK+ / ivermektiini. 16.11.2020 (covidcare.fi).
- Ehdotus: FinCCHTA: MATH+. 16.11.2020 (covidcare.fi).
Meta-analyysi (@CovidAnalysis/ivmmeta.com -ryhmä)
- Ivermektiini on vaikuttava COVID-19 -infektiossa: lähes reaaliaikaisesti päivitettävä meta-analyysi (ivmmeta.com).
- Ajantasainen luettelo valmistuneista kliinisistä kokeista (c19ivermectin.com).
- Ivermektiinin käyttöönoton tilanne kansainvälisesti (ivmstatus.com). Euroopassa ivermektiini on virallisesti otettu käyttöön COVID-19:n hoidossa Slovakiassa ja Tsekissä (tilanne 03/2021).
- Ivermectin is effective for COVID-19: meta analysis of 46 studies. 17.3.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 43 studies. 4.3.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 41 studies. 18.2.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 35 studies. 20.1.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 32 studies. 13.1.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 28 studies. 2.1.2021 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 26 studies. 18.12.2020 (covidcare.fi).
- Ivermectin is effective for COVID-19: meta analysis of 21 studies. 26.11.2020 (covidcare.fi).
- Arvio turhaan kuolleiden määrästä (c19legacy.com).
FLCCC-ryhmän hoitomenetelmät
I-MASK+ / ivermektiini
- Yhden sivun yhteenveto ivermektiinitutkimuksesta (covid19criticalcare.com).
- I-MASK+ -menetelmän perusteellinen kuvaus (covid19criticalcare.com). Laajempi tutkimuskatsaus.
- Ivermectin — a potential global solution to the pandemic (covid19criticalcare.com). Suppeampi tutkimuskatsaus.
- I-MASK+ -menetelmä (covid19criticalcare.com). Yleiskuvaus.
- Paul E. Marik: COVID-19 Rx Meta-analysis, 25.11.2020 (covidcare.fi). Kliinisten kokeiden meta-analyysi.
- FAQ on ivermectin (covid19criticalcare.com).
MATH+
- Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org). MATH+ -menetelmän perusteet vertaisarvioituna artikkelijulkaisuna.
- Scientific Review of COVID-19 and MATH+ (covid19criticalcare.com). Katsaus menetelmän perusteisiin.
- MATH+ käännöksineen (covid19criticalcare.com). MATH+ -menetelmän yleiskuvaus.
- Eastern Virginia Medical School: COVID Care Protocol for Clinicians (www.evms.edu). Yksityiskohtaisempi ja nopeammin päivittyvä "alkuperäinen" versio protokollasta. Ivermektiini on ollut vaihtoehtoinen komponentti 11.5.2020 alkaen mutta se on nostettu olennaiseksi komponentiksi 29.10.2020 alkaen.
Kehittäjätiimi
Professori Marik on julkaissut yli 400 vertaisarvioitua akateemista artikkelia ja huomattavan määrän muita julkaisuja (h-indeksi 89, 31000 viittausta). Professori Gianfranco Umberto Medurin h-indeksi on 64 ja hänellä on 17600 viittausta. Professori Joseph Varonin h-indeksi on 43 (8600 viittausta). Apulaisprofessori Pierre Koryn h-indeksi on 15 (lähes 800 viittausta). Apulaisprofessori Jose Iglesiasin h-indeksi on 14 (yli 600 viittausta). Lisäksi tiimiin kuuluu muita asiantuntijoita.
- Paul E. Marik, MD, FCCP, FCCM (www.evms.edu).
- ResearchGate: Paul E. Marik (www.researchgate.net).
- ResearchGate: Pierre Kory (www.researchgate.net).
- ResearchGate: Gianfranco Umberto Meduri (www.researchgate.net).
- ResearchGate: Joseph Varon (www.researchgate.net).
- ResearchGate: Jose Iglesias (www.researchgate.net).
- Koko tiimi (covid19criticalcare.com).
- FLCCC Contributions to the Field of Medicine (covid19criticalcare.com).
Akateemisia julkaisuja and kliinisiä kokeita
Julkaisuluettelo on 1.12.2020 tasalla.
Ks. myös ajantasainen ja kattava RCT-katsaus sivulla c19ivermectin.com ja meta-analyysi sivulla ivmmeta.com.
Tässä osassa on kuitenkin katsaus- ja teorialähteitä ivermektiinistä sekä lähteitä MATH+ -metodista, joita ei mainita em. sivuilla.
Ivermektiini: ennaltaehkäisyä koskevia kliinisiä kokeita
- Shouman W et.al: Prophylactic Ivermectin in COVID-19 Contacts. NCT04422561. 27.8.2020 (clinicaltrials.gov). 7 % sai tartunnan vs. 58 % vertailuryhmässä.
- Carvallo HE et.al.: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR). NCT04425850. 19.11.2020 (clinicaltrials.gov). 0 % sai tartunnan vs. 11 % vertailuryhmässä.
- Behera P, Patro BK, Singh AK, et al.: Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study. 3.11.2020 (doi.org). 73 % vähemmän infektioita.
- Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. 16.11.2020 (doi.org). 2 % sai tartunnan vs. 10 % vertailuryhmässä.
Ivermektiini: sairaalahoitoa koskevia kliinisiä kokeita
- Mahmud R. et.al.: Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection (NCT04523831) (clinicaltrials.gov). Results: early clinical improvement: 60% vs 44%; late clinical improvement: 23% vs 37%; clinical deterioration: 8% vs 18%; persistently RT-PCR positive: 8% vs 20%; adverse events: 2 vs 0; deaths: 0 vs 3
- Hashim HA, Maulood MF, Rasheed AM, Fatak DF, Kabah KK, Abdulamir AS: Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq (NCT04591600). medRxiv 27.10.2020 (www.medrxiv.org). pienempi kuolleisuus ja lyhentyneet hoitoajat.
- Elgazzar A, Hany B, Youssef SA, Hafez M, Moussa H, eltaweel A. Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic. 16.11.2020 (doi.org). 90 % pienempi kuolleisuus; lyhyempi sairaalassaoloaika.
- Niaee MS, Gheibi N, Namdar P, Allami A, Zolghadr L, Javadi A, Karampour A, Varnaseri M, Bizhani B, Cheraghi F, Naderi Y, Amini F, Karamyan M, Yadyad MJ, Jamshidian R: Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial. Research Square 24.11.2020 (doi.org). 82 % alempi kuolleisuus.
- Krolewiecki, Alejandro and Lifschitz, Adrián and Moragas, Matías and Travacio, Marina and Valentini, Ricardo and Alonso, Daniel F. and Solari, Rubén and Tinelli, Marcelo Adrián and Cimino, Ruben Oscar and Álvarez, Luis and Fleitas, Pedro Emanuel and Ceballos, Laura and Golemba, Marcelo Darío and Fernández, Florencia and Fernández de Oliveira, Diego and Astudillo, Germán and Baeck, Inés and Farina, Javier and Guthmann, Marcelo David and Cardama, Georgina A. and Mangano, Andrea and Spitzer, Eduardo and Gold, Silvia and Lanusse, Carlos, Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial. SSRN Electronic Journal 2020. (doi.org). merkittävästi pienempi viruskuorma potilailla, joilla ivermektiinin plasmapitoisuudet olivat korkeat.
Ivermektiini: vertailevia tutkimuksia
- Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter J-J: Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019. Chest 2020 (doi.org). kuolleisuus 13 % vs. 25 %.
- Hellwig MD, Maia A: A COVID-19 Prophylaxis? Lower incidence associated with prophylactic administration of Ivermectin. International Journal of Antimicrobial Agents 2020;106248 (doi.org). 80 % vähemmän tartuntoja.
- Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O: Bénéfice de l’ivermectine : de la gale à la COVID-19, un exemple de sérendipité. Annales de Dermatologie et de Vénéréologie 2020;147(12):A194 (doi.org). 0 % vs. 5 % kuolleisuus, 0 % vs 22.6 % vakava sairausmuoto.
- Guerrero R, Bravo L, Muñoz E, Grillo Ardila E, Guerrero E: COVID-19: The Ivermectin African Enigma. Colombia Médica 2020;51(4):e-2014613 (colombiamedica.univalle.edu.co).
- Brian C. Procter, Casey Ross, Vanessa Pickard, Erica Smith, Cortney Hanson, Peter A. McCullough. Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection. Reviews in Cardiovascular Medicine 2020;21(4):611–4 (doi.org).
Ivermektiini: pitkittynyt / post-akuutti syndrooma
- Aguirre Chang G, Saavedra E, Yui Cerna M, Trujillo Figueredo A, Córdova Masías JA: Post-acute or prolonged COVID-19: Treatment with ivermectin for patients with persistent or post-acute symptoms. ResearchGate 2020 (www.researchgate.net).
Ivermektiini: katsauksia ja teoriaa
- Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. Front Pharmacol 2021. doi: 10.3389/fphar.2021.643369 (web.archive.org).
- Kory P, Meduri G, Iglesias J, Varon J, Berkowitz K, Kornfeld H, Vinjevoll E, Mitchell S, Wagshul F, Marik PE: Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19. OSF Preprints 2020 (osf.io).
- Andrew Hill, Ahmed Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn McCann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel: Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection. Research Square 19.1.2021 (doi.org). The "WHO meta-analysis".
- Scheim D: Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion. SSRN Electronic Journal, 26.6.2020 (doi.org).
- Chamie J: Real-World Evidence: The Case of Peru. Causality between Ivermectin and COVID-19 Infection Fatality Rate. 2020 (www.researchgate.net).
- Pandey S, Pathak SK, Pandey A, Salunke AA, Chawla J, Sharma A, Sharma S, Thivari P, Ratha HVK: Ivermectin in COVID-19: What do we know? Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2020;14(6):1921-2. (doi.org).
- Sparavigna AC: Ivermectin for Covid-19. Working paper. Zenodo 20.9.2020 (doi.org).
- Elkholy KO, Hegazy O, Erdinc B, Abowali H: Ivermectin: A Closer Look at a Potential Remedy. Cureus 2020. (doi.org).
- Scheim D: Antimalarials for COVID-19 Treatment: Rapid Reversal of Oxygen Status Decline with the Nobel Prize-Honored Macrocyclic Lactone Ivermectin. SSRN Electronic Journal 3.6.2020 (doi.org).
- Rizzo E: Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. Naunyn Schmiedebergs Arch Pharmacol 2020 May 27: 1–4. PMC7251046 (doi.org).
- Morgenstern J, Redondo JN, De León A, Canela JM, Torres N, Tavares J, Minaya M, López Ó, Plácido AM, Castillo A, Peña Cruz R, Merette Y, Toribio M, Francisco JA, Roca S: The use of compassionate Ivermectin in the management of symptomatic outpatients and hospitalized patients with clinical diagnosis of COVID-19 at the Medical Center Bournigal and the Medical Center Punta Cana, Rescue Group, Dominican Republic, from may 1 to august 10, 2020. medRxiv 2020.10.29.20222505. 3.11.2020 (doi.org).
- Parth Sarthi Sen Gupta and Satyaranjan Biswal and Saroj Kumar Panda and Abhik Kumar Ray and Malay Kumar Rana: Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin. Journal of Biomolecular Structure and Dynamics 2020 (doi.org).
- Lawrie T: Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance. E-BMC Ltd 3.1.2021 (bit.ly).
- McCullough PA, Alexander PE, Armstrong R, Arvinte C, Bain AF, Bartlett RP, et al.: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine 2020;21(4):517-530 (doi.org).
- Ramírez, Céleo et al.: Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis? Lancet EClinicalMedicine, 100744, Feb 4, 2021 (doi.org).
MATH+
- Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine. December 2020 (doi.org).
- Marik PE, Kory P, Varon J, Iglesias J, Meduri GU. MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale. Expert Rev Anti Infect Ther 2020;18:1-7. doi: 10.1080/14787210.2020.1808462. PMID: 32809870 (covid19criticalcare.com).
- Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H, Peng Z-Y: Pilot Trial of High-dose vitamin C in critically ill COVID-19 patients. Preprint. Research Square 23.9.2020 (doi.org).
- Kory P, Kanne JP: SARS-CoV-2 organising pneumonia: Has there been a widespread failure to identify and treat this prevalent condition in COVID-19? BMJ Open Respiratory Research 2020;7:e000724 (doi.org). Explains the 'happy hypoxia'.
- Arvinte C, Singh M, Marik PE: Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020. A pilot study. Medicine in drug discovery 2020 (doi.org). This pilot study found low serum levels of vitamin C and vitamin D in most of the critically ill COVID-19 ICU patients. Older age and low vitamin C level appeared co-dependent risk factors for mortality.
- Chiscano-Camón L, Ruiz-Rodriguez J, Ruiz-Sanmartin A et al.: Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care 2020;24:522 (doi.org).
- Honore PM, Spapen HD, Marik PE et. al.: Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care 2020;10:23 (doi.org).
- Jovic TH, Ali SR, Ibrahim N, Jessop ZM, Tarassoli SP, Dobbs TD, Holford P, Thornton CA, Whitaker IS: Could Vitamins Help in the Fight Against COVID-19? Nutrients 2020;12:2550 (doi.org).
- Marik PE, Payen D: CITRIS-ALI: How statistics were used to obfuscate the true findings. Anaesthesia Critical Care & Pain Medicine 2019;38(6):575–577. Doi: 10.1016/j.accpm.2019.10.004 (www.researchgate.net).
- Fowler AA, Fisher BJ, Kashiouris MG: Vitamin C for Sepsis and Acute Respiratory Failure. JAMA 2020;323(8):792–3 (doi.org). CITRIS-ALI -raportin metodisten virheiden korjaus, jonka seurauksena mSOFA-mittari muuttuu tilastollisesti merkitseväksi 96 tunnin kohdalla.
- Frommelt MA, Kory P, Long MT: Letter on Update to the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Protocol. Trials 2020;21:350 (doi.org).
- Fowler AA, Syed AA, Knowlson S et. al.: Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014;12:32 (doi.org). Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
- Mao E: Intensive management of severe acute pancreatitis. Annals of Translational Medicine 2019;7(22) (atm.amegroups.com). High-dose intravenous vitamin C has been routinely used for various conditions in some intensive care units in China for a decade.
- Hemilä H, Chalker E: Vitamin C as a Possible Therapy for COVID-19. Infection & Chemotherapy 2020;52(2):222-223 (doi.org).
Uutisartikkeleita
I-MASK+ / ivermektiini
- How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru. TrialSite News 12.6.2020 (www.trialsitenews.com).
- Well-Respected Australian Researcher: Consider Triple Therapy (Ivermectin, Zinc, Doxycycline) for COVID-19. TrialSite News 4.8.2020 (www.trialsitenews.com).
- Australian GPs Can Legally Prescribe Ivermectin Triple Therapy Protocol — Professor Thomas Borody. 19.8.2020 (covexit.com).
- Argentina’s IVERCAR Ivermectin & Carrageenan Study Shows Positive Results Targeting COVID-19. TrialSite News 3.9.2020 (www.trialsitenews.com).
- An Old Drug Tackles New Tricks: Ivermectin Treatment in Three Brazilian Towns. TrialSite News 16.9.2020 (www.trialsitenews.com).
- Ivermectin Works and Should be Accepted for Large Observational Studies. Trialsite News 28.10.2020 (www.trialsitenews.com).
- Real World Evidence? I-MASK+ Protocol: Ivermectin Key for Prophylaxis and Early Treatment of COVID-19. TrialSite News 3.11.2020 (www.trialsitenews.com).
- Benha University Breakthrough: Randomized Controlled Trial Shows Ivermectin Effective for Treating COVID-19 & as Prophylaxis. TrialSite News, 14.11.2020 (www.trialsitenews.com).
- Why Isn’t Ivermectin Being Widely Researched and Utilized? TrialSite News 15.11.2020 (www.trialsitenews.com).
- Joseph A. Ladapo: Too Much Caution Is Killing Covid Patients. Doctors should follow the evidence for promising therapies. Instead they demand certainty. Wall Street Journal 24.11.2020 (www.wsj.com).
- Carvallo H. et.al.: Resultados positivos del protocolo IVER.CAR en la profilaxis de los agentes de salud. 2020 (www.pharmabaires.com).
- ICDDR Dhaka Bangladesh Completes Successful Ivermectin Clinical Trial. TrialSite News, 9.12.2020 (trialsitenews.com).
- US Senate Hearing Explores Ivermectin as “Miracle Drug” for COVID-19 While Mainstream Media Outlets Ignore. TrialSite News, 11.12.2020 (trialsitenews.com).
- Introducing the Physicians for Civil Defense: Prominent Doctors Know Ivermectin can Help Treat COVID-19: Will Anyone Listen? TrialSite News, 11.12.2020 (trialsitenews.com).
- Beyond The Roundup | Senate Hearing On Ivermectin Brings Unexpected Drama. TrialSite News, 12.12.2020 (trialsitenews.com).
- Fact Checking the Fact Checkers: The Case of Ivermectin for Publicly-Subsidized Research. TrialSite News, 13.12.2020 (trialsitenews.com).
- Interview with Lawyer Jean-Charles Teissedre about Ivermectin. Covexit 13.12.2020 (covexit.com).
- Clinical Trials and Research Roundup | Doctors: Ivermectin Can Help Treat COVID: Will Anyone Listen? TrialSite News, 14.12.2020 (trialsitenews.com).
- Prasad, Amit Mohan: From control rooms to testing, several strategies helped UP contain pandemic. The Indian Express 17.12.2020 (indianexpress.com). Uttar Pradesh on käyttänyt ivermektiiniä ennaltaehkäisyyn ja avohoitoon heinäkuusta alkaen, ja ivermektiiniä ja doksisykliiniä sairaalahoidossa.
- Bangladesh Medical College Observational Study: Ivermectin Works as PrEP for Health Care Workers Against COVID-19. TrialSite News, 17.12.2020 (trialsitenews.com).
- Webinar with Professor Paul Marik: the Prevention & Outpatient Treatment of C19. Covexit 17.12.2020 (covexit.com).
- MedinCell’s Mission for ‘Mass Roll-out’ of Ivermectin for COVID-19: Early Study Data Points Reveal Promise. TrialSite News, 18.12.2020 (trialsitenews.com).
- Ivermectin Shows Potential as a Promising COVID-19 Prophylactic According to Study Published in Peer-Review Journal. TrialSite News, 19.12.2020 (trialsitenews.com).
- Ivermectin to Save Belgium? Covexit 22.12.1010 (covexit.com).
- MALMED will approve Ivermectin, but then will ask the pharmaceutical companies to bring it because "it is not a cure for business". 24.12.2020 (www.slobodenpecat.mk).
- Bulgarian Prof. Ivo Petrov: Ivermectin Plays The Role of A Live Vaccine. 24.12.2020 (www.novinite.com).
- Did you Hear about the ZIVERDO Therapy for COVID-19? Covexit 26.12.2020 (covexit.com).
- Mary Beth Pfeiffer: In Far-Flung Places, COVID-19 Is Being Treated Early And Well. Here’s Why Americans Don’t Know This. TrialSite News 27.12.2020 (trialsitenews.com).
- Macedonia Nears Approval of Ivermectin for COVID-19 as Word of the Drug Spreads in the Balkan Peninsula. TrialSite News 28.12.2020 (trialsitenews.com).
- Unitaid, Part of the World Health Organization Funding Ivermectin Research Targeting COVID-19 led by British Expert. TrialSite News 29.12.2020 (trialsitenews.com).
- Can Ivermectin be used to treat COVID-19 (coronavirus)? Drugs.com 29.12.2020 (www.drugs.com).
- Beyond The Roundup | Central American Nation of Belize Authorizes Use of Ivermectin for COVID-19. TrialSite News 30.12.2020 (trialsitenews.com).
- Prof. Ivo Petrov for Ivermectin: The Study Is Over, The Results Are Encouraging. 31.12.2020 (www.novinite.com).
- WHO-sponsored preliminary review indicates Ivermectin effectiveness. 31.12.2020 (swprs.org).
- Paul E. Sax: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? NEJM Journal Watch 4.1.2021 (blogs.jwatch.org).
- NIH COVID-19 Treatment Guidelines Panel Invites Top Ivermectin Researchers to Discuss the Evidence of Efficacy to Date. 8.1.2020 (trialsitenews.com).
- Growing Momentum for Ivermectin in German Press as Pharmacy Journal Introduces Ivermectin as Possible Treatment for COVID-19. TrialSite News 17.1.2021 (trialsitenews.com).
- Barcelona Institute for Global Health (ISGlobal): A clinical trial provides encouraging results on ivermectin for reducing mild COVID-19. 19.1.2021 (www.eurekalert.org).
- Donato Paolo Mancini: Cheap antiparasitic could cut chance of Covid-19 deaths by up to 75%. Financial Times 20.1.2021 (www.ft.com).
- Spanish Pilot Study Reveals Ivermectin Can Possibly Reduce Viral Transmission. TrialSite News 21.1.2021 (trialsitenews.com).
- Rhys Blakely: Trial for Covid ‘wonder drug’ that could save thousands of lives. The Times (UK), 23.1.2021 (www.thetimes.co.uk).
- Ministério Público Federal (Brazil): Covid-19: Conselho Federal de Medicina ressalta autonomia do médico e do paciente na utilização de medicamentos e procedimentos. 23.1.2021 (www.mpf.mp.br). physicians are officially allowed autonomous decisions regarding treatment of COVID-19 patients.
- Financial Times Adds to Argument for Ivermectin. TrialSite News 23.1.2021 (trialsitenews.com).
- Oxford’s PRINCIPLE Trial: Bringing Ivermectin Directly into the Developed World in the Battle Against COVID-19. TrialSite News 23.1.2021 (trialsitenews.com).
- Jackie Cameron: Ivermectin: Major tech breakthrough in human application, as scientists aim to save world from Covid-19 and malaria. 11.2.2021 (www.biznews.com).
- Belgian Virologist Proposes a Plan to Eradicate COVID-19 in 6 Weeks Using Ivermectin. TrialSite News 13.2.2021 (trialsitenews.com).
- Beyond The Roundup | Bill and Melinda Gates Fund Global Ivermectin Clinical Trial. TrialSite News 13.2.2021 (trialsitenews.com).
- Merck Spends Big on COVID-19 Candidate, But Ignores Its Own Ivermectin Product. TrialSite News 14.2.2021 (trialsitenews.com).
- Large Dominican Real World Observational Study with Compassionate Ivermectin Use Points to Strong Efficacy Signal. TrialSite News 14.2.2021 (trialsitenews.com).
- Catherine Offord: Frontiers Removes Controversial Ivermectin Paper Pre-Publication. The Scientist 2.3.2021 (www.the-scientist.com).
- Two Groups Review Evidence for Ivermectin Very Differently. TrialSite News 4.3.2021 (trialsitenews.com).
MATH+
- Busby, Mattha: Holistic Approaches May Have Reduced Coronavirus Deaths at This London Hospital. Vice 8.10.2020 (www.vice.com).
- Farkas, Josh: PulmCrit- CITRIS-ALI: Can a secondary endpoint stage a coup d’état? Emcrit.org 1.10.2019 (emcrit.org). Farkas on Vermontin yliopiston tehohoidon ja keuhkosairauksien apulaisprofessori.
- Do the MATH+: COVID-19 Protocol of Steroids and Vitamin C Divides Experts. Trialsite News 24.6.2020 (www.trialsitenews.com).
- Small, Taurean: Senate committee explores COVID-19 recommendations from local expert. Spectrum News 1 6.5.2020 (spectrumnews1.com).
- Kamen, Joyce: “We’ve Cracked the COVID-19 Code.” (And Why No One is Listening.) Medium, 16.4.2020 (medium.com).
- Kamen, Joyce: The Facts on Why Tens of Thousands of Americans Died Needlessly from COVID19. 31.8.2020 (medium.com).
- Naley Andersen, Amalie ja Jonsrud Pedersen, Karine: Fortsetter med C-vitaminbehandling. Nærnett.no 27.2.2020 (www.nernett.no).
- Blok, Camilla: Legene uenige om «mirakelkur». TV2 Nyheter 9.1.2020 (www.tv2.no).
Videoita
I-MASK+ / ivermektiini
- TrialSite News Roundup: Dr. Tess Lawrie Discusses her Ivermectin Meta-Analysis, the FDA, and Dr. Andrew Hill. 15.3.2021 (youtu.be).
- Dr. John Campbell: Ivermectin Evidence with Dr Tess Lawrie. 6.3.2021 (youtu.be).
- Pierre Kory: The Efficacy of Ivermectin Against COVID‑19. Jan 27, 2021 (covid19criticalcare.com).
- Dr. Tess Lawrie's systematic review. 25.1.2021 (youtu.be).
- NIAID Advisory Council Meeting - January 2021. National Institute of Allergy and Infectious Diseases, 25.1.2021 (videocast.nih.gov). Dr. Anthony S. Fauci addresses the full council.
- Ivermectin meta-analysis by Dr. Andrew Hill. 27.12.2020 (youtu.be). WHO:n meta-analyysista.
- Fusion Healthcare Webinar: COVID-19, Vitamin C and I-MASK. Paul Marik and Deepak Govil (India). 23.12.2020 (youtu.be).
- Ivermectin - A Game Changer for COVID-19? Christy Risinger. 22.12.2020 (youtu.be).
- COVID-19 Learn how to PROTECT YOURSELF as our Hospitals are Brought to their Knees. Jennifer Hibberd. 20.12.2020 (youtu.be).
- Ivermectin and COVID 19. John Campbell. 12.12.2020 (youtu.be).
- Dr. Pierre Kory (FLCCC Alliance) testifies to senate committee about I-MASK+ (incl. the following Q&A part). 8.12.2020 (vimeo.com).
- FLCCC Alliance News Conference: Medical Evidence of Ivermectin— Effectively Prevent & Treat COVID19. 4.12.2020 (youtu.be).
- Drbeen Medical Lectures: Dr. Paul Marik Discusses His I-MASK+ Protocol. 24.11.2020. (youtu.be).
- Clinical Trials and Research News Weekly Roundup | I-MASK+: Ivermectin Key For Early Treatment. TrialSite News 16.11.2020 (youtu.be).
- Dehgani-Mobaraki, Puya and Kory, Pierre: Review of the Emerging Evidence For Use of Ivermectin in the Prophylaxis and Treatment of COVID. Associazione Naso Sano Provider ECM, Nov 14, 2020 (youtu.be).
- FLCCC Alliance: I-MASK+. 10.11.2020 (vimeo.com). Suurelle yleisölle suunnattu johdanto.
- Whiteboard Doctor: Interview With Dr. Hector Carvallo: Pioneer In Ivermectin, Iota Carrageenan, Bromhexine And COVID-19. 5.11.2020 (youtu.be).
- Pierre Kory (FLCCC Alliance) on the importance of Ivermectin in the treatment of COVID-19. 30.10.2020 (vimeo.com).
- Marik, Paul: COVID 19: Ivermectin Update. 27.10.2020 (youtu.be).
- TrialSite News: Clinical Trials and Research News Weekly Roundup | Ivermectin Treatment in Three Brazilian Towns. 28.9.2020 (youtu.be).
- Tratamiento Temprano: Preview of study ivermectin antiviral effectiveness Argentina. 19.9.2020 (youtu.be).
- Clinical Trials and Research News Weekly Roundup | Zagazig University Ivermectin VS COVID-19. TrialSite News 7.9.2020 (youtu.be).
- Drbeen Medical Lectures: An Ivermectin Prophylaxis Study From India. 5.11.2020. (youtu.be).
- Drbeen Medical Lectures: Good News Ivermectin Reduces Mortality In COVID-19 Patients. 4.11.2020. (youtu.be).
- Drbeen Medical Lectures: Ivermectin Works For COVID-19 - Latest studies. 19.10.2020. (youtu.be).
- Drbeen Medical Lectures: Ivermectin, Abbott, Dogs, ICM Protocol. 26.9.2020 (youtu.be).
- TrialSite News Original: Documentary in Peru about Ivermectin and COVID-19. TrialSite News 14.8.2020 (trialsitenews.com).
- Clinical Trials and Research News Weekly Roundup | S2 E27 | Ivermectin VS Hydroxychloroquine. TrialSite News, 6.7.2020 (youtu.be).
- Dr. Weller: IVERMECTINA COVID 19. May 17, 2020 (youtu.be).
- Christy Chrisinger: Ivermectin for the Treatment of COVID - UPDATE 1/20/2021. 20.1.2021 (youtu.be).
- TratamientoTemprano: WHO Ivermectin news in next 6 weeks. 15 Feb 15, 2021 (youtu.be). Dr. Sylvie Briand and Dr. Maria Van Kerkhove (technical lead for COVID-19)
MATH+
- Marik, Paul: COVID 19: A Clinical Update. 17.10.2020 (youtu.be).
- Paul Marik's YouTube channel (www.youtube.com).
- U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: How New Information Should Drive Policy (www.hsgac.senate.gov).
- Drbeen Medical Lectures: COVID-19 Management With Dr. Paul Marik - Author Of MATH+ Protocol. 15.9.2020 (youtu.be).
- Drbeen Medical Lectures: COVID-19 Patient Management with Dr. Paul Marik (Author of MATH+ Protocol). 15.7.2020 (youtu.be).
- US National Institute of Health (NIH) Speaker Series Webinar: The role of vitamin C in the treatment and prevention of COVID-19. Richard Cheng (MD, PhD). 8.4.2020 (youtu.be).
- Meet the "Covid Hunter" of Houston. BBC News, 29.7.2020 (www.bbc.com). Dr Joseph Varon is the Chief of Critical Care at UMMC Houston. He says he has adapted a treatment protocol that has given his Covid-19 patients a 95% chance of recovery.
Podcasteja
- Dr. Pierre Kory Talks Covid-19, Ivermectin and the FLCCC | Podcast E43. TrialSite News, 25.11.2020 (www.trialsitenews.com).
- Charles Adler Tonight: Ivermectin as a potential covid therapeutic. Nov 18, 2020 (omny.fm).
- Alan Cannell talks COVID-19: Nobody Likes Cheap Solutions | Podcast S2 E41. TrialSite News, 11.11.2020 (www.trialsitenews.com).
Sivustoja
- COVID-19 studies for ivermectin (c19ivermectin.com).
- The COVID-NMA initiative: a living mapping and living systematic review of Covid-19 trials (covid-nma.com).
- TrialSite News: Ivermectin (trialsitenews.com).
- Twitter: Dr Andrew Hill (twitter.com). Author of the WHO related meta-analysis
- USA:n National Institute of Health:n ivermektiinilinjaus 14.1.2021 (www.covid19treatmentguidelines.nih.gov).
- USA:n National Institute of Health:n ivermektiinilinjaus 27.8.2020 ().
- ECDC:n maakohtaiset katsaukset (covid19-country-overviews.ecdc.europa.eu).
- Perun valtion avoin data: COVID-19 -tilastotiedot (www.datosabiertos.gob.pe).
- icumonitoring.ch (icumonitoring.ch). Sveitsin tehohoidon resurssitilanteen seuranta.
- Frontline COVID-19 Critical Care Alliancen Facebook-sivu (www.facebook.com).
- Lucy Kerr: Alguns esclarecimentos sobre a ivermectina (portallucykerr.com). "taxi24hs on Nov 4, 2020 at 9:05 am: Here in Brasil, two city mayors (Itajaí and Natal), who are also medical doctors, made ivermectin available to citizens, at no cost. To get the drug, the person has to get registered in the health system. This data is shared with the local university. Imagine the value of this wealthy data (thousands of patients) to present and future studies about the benefits of this drug. A medical doctor, image diagnosis expert, Dr. Lucy Kerr, leads a 570 medical doctors team. This team is treating patients with ivermectin, both in prevention care and already sick patients. This team has developed protocols which are based on ivermectin. Her site (in portuguese).
- Reddit: r/ivermectin (www.reddit.com).
- Reddit: r/covidlonghaulinfo/ (www.reddit.com).
- PeakProsperity on ivermectin, 29.12.2020 (www.peakprosperity.com).
- A reddit discussion on FDA and ivermectin. 2.1.2021 (www.reddit.com).
- Ivermectin vs. COVID-19 blog / list of news (thefoolishnessofgod.blogspot.com).
- PubChem: Ivermectin (pubchem.ncbi.nlm.nih.gov).
- Covexit.com: Ivermectin (covexit.com).
- COVID-19 Related Clinical Studies Spreadsheet (aact.ctti-clinicaltrials.org).
- Uttar Pradesh COVID-19 Tracker (www.bing.com).
- Twitter: Juan Chamie (twitter.com).
- Information in French (ivermectine-covid.ch).
FLCCC-metodit Euroopassa
- Eivind Hustad Vinjevoll, Volda, Norja (www.facebook.com). Teho-osaston ylilääkäri, Voldan sairaala, Norja
- Scott Mitchell, Princess Elizabeth Hospital, Guernsey, UK (www.linkedin.com). MRCS, Associate Specialist Emergency Medicine
- Rolf Ensner, Kantonsspital Aarau, Sveitsi (www.ksa.ch).
- Puya Dehgani-Mobaraki, Gubbio-Gualdo Tadino Hospital, Italia (puyadehgani.com).
- Francesco Savelli, ER & Emergency Medicine Hospital of Faenza, Italia (www.auslromagna.it). Pronto Soccorso e Medicina d’Urgenza Ospedale per gli Infermi di Faenza
- Fabrizio Pedrabissi, Finale Emilia, Italia ().
- Marco Confalonieri, Professor of Medicine, University of Trieste ().
- Markus Hell, Paracelsus Medical University, Salzburg, Austria ().
- Gregor Zasmeta, Krankenhaus der Barmherzigen Brueder Wien, Vienna, Austria ().
- Jose Luis Diaz-Penalver Gonzalez, Institut Catala Salut, Catalonia, Spain ().
- Peer Schleyerbach, Arlesheim, Switzerland ().
- Bettina Schleyerbach, Arlesheim, Switzerland ().
- Paul Robert Vogt, University Hospital/Zurich, Zurich, Switzerland ().
- Artur Bartosik, Krakow, Poland ().
- George P. Chrousos, Professor of Pediatrics and Endocrinology, Holder of the UNESCO Chair on Adolescent Health Care at the University of Athens, Greece ().
- Franz Brettner, Senior Physician, Head of Department, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
- Werner Appelt, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, pain medicine, palliative care, Barmherzige Brüder Hospital, Munich, Germany ().
- Florian Brettner, Senior Physician, Specialist in anesthesiology, intensive care medicine, emergency medicine, Barmherzige Brüder Hospital, Munich, Germany ().
- Tina Peers, United Kingdom, Surrey, London ().
- Leonardo Reyes Ortiz, Hospital CIMA, Barcelona, Spain ().
- Artur Bartosik, Krakow, Poland ().
- Tomasz Zawada, Wroclaw, Poland ().
- Tijana Cer Stoja, Emergency Service Novi Sad, Serbia ().
- Pavol Torok, Clinic AIM, East Slovakian Institute of Cardiovascular Diseases, Kosice, Slovakia ().
- Arber Hoti, University of Pristina, Kosovo ().
- Mereu Giovanni Antonio, Cagliari, Italy ().
- Simon Rauch, Intensive Care Unit, Merano Hospital, Italy ().
- Francesco Raggi, Terni, Italy ().
- Plino Calligaro, Villafranca di Verona, Italy ().
- Zsuzsanna Rago, Albert Szent-Gyorgyi Clinical Center of Szeged University, Hungary ().
- Theodoros Aslandis, St. Paul General Hospital, Thessaloniki, Greece ().
- Patrick Jeanmougin, Strasbourg, France ().
- Matthias Judex, Talissieu, France ().
- Michal Rezek, St. Anne University Hospital, Brno, Czech Republic ().
- Nikolay Uvaliev, Acibadem City Clinic - University Hospital Sofia, Bulgaria ().
MATH+ -menetelmän historiasta
Alkuvaiheessa menetelmän käyttöönottoa haittasi WHO:n ohjeistus glukokortikoidien välttämisestä. WHO muutti ohjeistustaan vasta syyskuussa 2020.
- The FLCCC Alliance Story (covid19criticalcare.com).
- World Health Organization: WHO updates clinical care guidance with corticosteroid recommendations. 2.9.2020 (www.who.int).
- U.S. Senate Committee on Homeland Security & Governmental Affairs: Hearings – Roundtable – COVID-19: Testimony of Pierre Kory, M.D., M.P.A., Critical Care Service Chief, Associate Professor of Medicine, University of Wisconsin School of Medicine and Public Health (www.hsgac.senate.gov). Yhdysvaltojen senaatille 6.5.2020 esitetty materiaali.
Organisaatioita
- Front Line Covid-19 Critical Care Alliance (covid19criticalcare.com). Tehohoitoasiantuntijoiden yhteenliittymä, joka edistää MATH+ -menetelmän käyttöä.
Contact information: info _ covidcare fi